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Characterizing the stem cells responsible for lung repair and regeneration is important for the treatment of pulmonary diseases. Recently, a unique cell population located at the bronchioalveolar-duct junctions has been proposed to comprise endogenous stem cells for lung regeneration. However, the role...
development and regeneration19,20,21,22. While genetic and histological evidence strongly suggest that endothelial cells play a key role in ACDMPV pathogenesis4,14, endothelial cell diversity and key signaling pathways in ACDMPV remain unclear. The TGFβ/BMP signaling pathway has been implicated in ...
et al. The cellular and physiological basis for lung repair and regeneration: past, present, and future. Cell Stem Cell 26, 482–502 (2020). Article CAS PubMed PubMed Central Google Scholar Parekh, K. R. et al. Stem cells and lung regeneration. Am. J. Physiol. Cell Physiol. 319, ...
Evidence for lung repair and regeneration in humans: key stem cells and therapeutic functions of fibroblast growth factors Regeneration carries the idea of regrowing partially or completely a missing organ.Repair,on the other hand,allows restoring the function of an existing bu... X Chu,C Chen,...
Therefore, the detection of proliferative postnatal stem or progenitor cells that actively take part in repair and regeneration has been challenging. Numerous studies attempting to identify adult stem or progenitor candidates in the lung have used injury and disease models, primarily in rodents. To ...
or IPF for short. "The treatment options for IPF have been few and far between," explains Dr. Mareike Lehmann, scientisit in the Lung Repair and Regeneration Research Unit (LRR) at the Helmholtz Zentrum München. "We are therefore attempting to understand how the disease comes about so that...
The three R's of lung health and disease: repair, remodeling, and regeneration the lung responds to injury and disease, with a particular emphasis on recent studies describing the role for the epithelium in repair and regeneration.doi...
the scientists succeeded for the first time in identifying and quantifying the abundance and solubility of more than 8,000 proteins in the lung proteome throughout the multistage tissue repair processes. "The information we have gained about the dynamic changes in ECM composition and its interactions...
A better understanding of the processes that regulate lung development, particularly alveologenesis, will have a significant impact on survival rates for premature infants born with incomplete lung development and will facilitate lung injury repair and regeneration in adults. A consortium of four ...