We focused on crucial roles of lung progenitor cells in alveolar cell regeneration and epithelial barrier re〆stablishment and aimed to uncover a possible mechanism of lung repair after severe SARS〤oVinfection. Materials and methods Bronchoalveolar lavage fluid (BALF) of COVID patients was analysed ...
Bothcell typescan differentiate into lungepithelial cells, which cover the inner surfaces of the lungs where air exchange occurs. In so doing, they can repair lung damage caused by SARS-CoV-2, including fibrosis. The first step towards activating these regenerative cells is to prime the tissue ...
the incidence rate of post-COVID lung fibrosis can be estimated at 2–6% after moderate illness. What is worse, there are reasons to believe that fibrosis may become one of the major long-term complications of COVID, even in asymptomatic individuals. Currently, despite the best efforts of th...
Further experiments showed that this process hinges on the protein IL-33. Under normal conditions, IL-33 increases in the nuclei of lung stem cells in response to stress or injury and helps the lung repair damaged barriers. During and after infection, though, IL-33 can take on a more detri...
This could not only help in resolving inflammation, but also in suppressing the cytokine storm, promoting tissue repair thereby preventing COVID-19 related mortality [1]. As per our preliminary observations, LDRT appeared to be a promising modality for selected patients with moderate to severe CO...
Lung diseases triggered by endogenous or exogenous factors have become a major concern, with high morbidity and mortality rates, especially after the coronavirus disease 2019 (COVID-19) pandemic. Inflammation and an over-activated immune system can lead to a cytokine cascade, resulting in lung dysfu...
Sex differences in the anatomy and physiology of the respiratory system have been widely reported. These intrinsic sex differences have also been shown to modulate the pathophysiology, incidence, morbidity, and mortality of several lung diseases across t
We hypothesized that CAIP regulates lung injury repair after ARDS through the STAT3 signaling pathway, which is an important downstream effector of α7nAchR. We enhanced CAIP activity by subjecting rats to vagus nerve stimulation (VNS), and administered the α-7 acetylcholine receptor (α7nAchR) ...
But after chronic injury, like the damage done from decades of smoking, the lungs can only do so much to repair themselves, he says. Smoking causes two kinds of long-term damage to the lungs:emphysema and chronic bronchitis. Together, these are known aschronic obstructive pulmonary disease(COP...
Proportions were calculated across cells for healthy and COVID+ donors separately. Cell–cell interaction analysis Cell–cell interaction from scRNA-seq data was predicted using CellChat77. B plasma subsets were combined (B-plasma) and cell types of interest (B-naive, B-memory, SMG duct, SMG ...