RadiationfibrosismacrophagesPPARLung cancer continues to be the leading cause of cancer deaths and more than one million lung cancer patients will die every year worldwide. Radiotherapy (RT) plays an important role in lung cancer treatment, but the side effects of RT are pneumonitis and pulmonary ...
Genetic phenotypes: Genetic variation in crucial genes in DNA replication and repair, inflammation, and oxidative stress pathways, may either ameliorate or exacerbate the effects of a given radiation dose on the lungs. The risk of RP increases as the number of unfavorable genotypes increases (see ...
The treatment method of interstitial brachytherapy is considered as an effective and safe tool by reducing the side effects of radiotherapy and increasing the radiation dose of radiotherapy.Background Lung is one of the most sensitive tissues to radiation, which limits the dose and therapeutic effect...
Increased understanding of these mechanisms will suggest new strategies for improving the efficacy of radiation therapy while limiting toxic side effects. 展开 关键词: Radiation Radiation pneumonitis Pulmonary fibrosis..DOI: 10.1097/00045413-199909000-00003 ...
These techniques limit dose to surrounding normal tissue in an effort to reduce toxicity; however, despite such improvements, potentially serious side effects related to treatment may occur, requiring urgent management. Objective Radiation-related brain or lung injury in previously irradiated patients may...
The lung is one of the most sensitive tissues to ionizing radiation, thus, radiation-induced lung injury (RILI) stays a key dose-limiting factor of thoracic radiotherapy. However, there is still little progress in the effective treatment of RILI. Ras-rel
This study confirms that these effects are clinically tolerable to a certain degree in the current clinical context considering the various more critical dose uncertainties due to motion and range uncertainties in proton therapy.Background Since proposed for radiation therapy, ion beams are of ...
Radiation-induced antitumor effects have been linked to self-DNA leakage, cGAS–STING signaling and protective IFN-β [30]. However, caution is necessary as, in a mouse model, high radiation doses have been shown to induce DNA exonuclease TREX1 decreasing cGAS activity, while, in contrast, re...
"More education is needed forradiationoncologists, to prevent overtreatment—which has not been proven to further improve symptoms or quality of life, and can have some significant side effects," Koshy said. The researchers also looked for any particular type of patient more likely to be overtrea...
It has been approximately two decades since we started performing carbon ion radiation therapy (C-ion RT) for non-small cell lung cancer (NSCLC). In 1994, we started conducting clinical trials using the dose-escalation method to determine the optimal dose of radiation. The additional purpose was...