A particular strength of our study is that we used standardized methods to conduct the lung function testing and to obtain the respiratory diagnoses. All questionnaires and lung function tests were standardized and prospectively collected, were supervised by certified lung function technicians, and the ...
Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of lung function to date, comprising 588,452 participants, we identified 1,020 ind
smokers, and 56 men who started smoking presented findings close to those of persistent smokers.Decline in physical fitness and lung function among healthy middle aged men was considerably greater among smokers than among non-smokers and could not be explained by differences in age and physical ...
Endpoints evaluated were lung function (assessed by changes from baseline in FEV1 AUC0–12h, trough FEV1 [further analyzed according to background ICS use], and FVC at Week 12); health status (measured by changes from baseline in SGRQ total score and COPD Assessment Test [CAT™] score at...
We integrate keypoints correspondence into the loss function to increase the alignment of airways and vessels. Abstract Deep-learning-based registration methods emerged as a fast alternative to conventional registration methods. However, these methods often still cannot achieve the same performance as conv...
To predict the therapeutic mechanism of DM on ALI, we carried out GO and KEGG enrichment analyses, in which the GO enrichment analysis included biological processes (BP), cellular components (CC) and molecular functions (MF), which explained the biological function of genes at different levels. ...
(intestinal mucosa structure/function) and on the development of tolerogenic dendritic cells, which later on influence the local intestinal as well as the systemic immune response (reviewed in [140]). Thus, counteracting microbiome dysbiosis in allergy and asthma using probiotics seems worthwhile [141...
and emphysema volumes are increased in hospitalized patient in critical condition or died while residual healthy lung parenchyma is decreased (Table2). On the other hand, GGO volumes did not affect the patients outcome; this result is explained by the high percentage of GGO in all patients ...
Therefore, the aim of this study was to examine the association between lung function in individuals aged 30–49 years at baseline and the burden of OLD, both from a physiological and socioeconomical perspective, throughout 27 years of follow-up. The burden of OLD was based on the number of...
To better understand the mechanism underlying the observed changes in lung function inTrpml3−/−mice and to examine whether there is a direct link between TRPML3 expression/function in AMΦ and the observed emphysema phenotype, we performed different assays using BALF samples and AMΦ isolated...