The method comprises a step of administering to a pulmonary fibrosis patient in need thereof an effective amount of a compound of Formula 1, which is an arylpiperazine derivative.BHAT, LAXMINARAYAN
Influence of arsenic trioxide on bleomycin-induced lung fibrosis in rats and its mechanism 三氧化二砷对大鼠肺纤维化模型的干预作用及其机制的探讨 www.ilib.cn 9. Study on treatment and diagnosis of integrated traditional Chinese and western medicine on lung fibrosis in recovery stage of SARS SARS恢复期...
Ad Idiopathic pulmonary fibrosis (IPF), which affects about 100,000 people in the U.S. each year and leads to death within three years of diagnosis, has only one therapy in the U. S.:lung transplantation. Duke researchers have found a possible new treatment by identifying acell surface rec...
Pulmonary fibrosis is a kind of devastating interstitial lung disease due to the limited therapeutic strategies. Traditional Chinese medicine (TCM) practices have put forth Shenks as a promising treatment approach. Here, we performedin vivostudy andin vitrostudy to delineate the anti-fibrotic mechanism...
Pulmonary fibrosis is the end-result of a variety of pathological diseases and their associated processes. This article summarizes the diagnosis and management of some of the more common causes of fibrosis, outlines their natural histories and treatment outcomes, and describes the trade-off of ...
MFN1 or MFN2 deficiency in AEC2 cells promotes bleomycin-induced lung fibrosis. a Body weight changes of control (n = 18), Mfn1iΔAEC2 (n = 13) and Mfn2iΔAEC2 (n = 16) mice after bleomycin treatment. Data are mean±s.e.m. (results from 3 independent experiments; ...
Rev-erbα agonist prevents it. This study provides the potential of Rev-erbα agonists in the treatment of pulmonary fibrosis. Similar content being viewed by others Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFβ signaling through TGFBR1 stabiliza...
7E). Hence our data suggest that saracatinib could prove potent as a single agent in the treatment of mesothelioma in the clinic. Discussion Pleural mesothelioma (MPM) is accompanied by extensive fibrosis which is a major cause of symptoms and death. The microenvironment of MPM includes cancer-...
Lung cancer is a common malignant tumor that occurs in the human body and poses a serious threat to human health and quality of life. The existing treatment methods mainly include surgical treatment, chemotherapy, and radiotherapy. However, due to the st
Meprin β localisation changes upon bleomycin treatment In order to assess meprins expression in the bleomycin model of lung fibrosis, we performed immunohistochemical staining. Similar to the human data, meprin α and meprin β were localized mostly to epithelial cells and to inflammatory cells (Fig...