Influence of particle size on regional lung deposition-- what evidence is there? Int J Pharm, 406, 1-10.Carvalho, T. C., J. I. Peters, and R. O. Williams. 2011. Influence of particle size on regional lung deposition - What evidence is there? Inter- national Journal...
We will briefly describe this particle deposition model. The extra-thoracic deposition was calculated using the empirical correlations from Cheng et al.30. From their study, the deposition efficiency in the extra-thoracic region for either nasal or oral breathing is expressed as: ...
Lung depositionThe objective of this study was to investigate the feasibility of the Aerodynamic Particle Sizer (APS) and the Electrical Low-Pressure Impactor (ELPI) to study mass weighted particle size distributions. Unimodal and bimodal liquid test aerosols were produced to a small chamber. ...
Air particles vary greatly in size, pathogenicity, and concen- tration (e.g., rural vs. urban vs. occupational environ- ments). A key point is that particle size (diameter) is an important determinant of pulmonary deposition and clearance. Particles larger than 10 /..lm in diameter are ...
Prediction of Particle Deposition in the Human Lung Using Realistic Models of Lung Ventilation. Journal of Aerosol Science. 2006; 37 :1209–1221.Asgharian B, Price OT, Hofmann W. Prediction of particle deposition in the human lung using realistic models of lung ventilation. Aerosol Sci 2006;37...
Strong JC, Agnew JE (1989) The particle size distribution of technegas and its influence on regional lung deposition. Nucl Med Commun 10:425–430 PubMedCASGoogle Scholar Surette GD, Muir AL, Hogg JC, Fraser RG (1975) Roentgenographic study of blood flow redistribution in acute pulmonary edem...
Deposition percentages (DepT) are largest in the infant, compared to the adult and child subjects (Table 2); DepT increases with particle size for all age groups. While the majority of the 3 and 5 μμm diameter particles deposit in the lung, most of the 1 μμm particles are exhaled ...
Particle size dependent deposition and pulmonary inflammation after short-term inhalation of silver nanoparticles. Part Fibre Toxicol. 2014;11:49. Article PubMed PubMed Central Google Scholar Takenaka S, Karg E, Kreyling WG, Lentner B, Möller W, Semmler-Behnke M, Jennen L, Walch A, ...
It was also found that the decrease in particle size to below 1 μm lead to a significant decrease in the total lung deposition. The narrow size distribution of the microparticles should also increase the effectiveness of their deposition in deeper parts of the respiratory tract [29]. One ...
A dry powder inhalable formulation of salvianolic acids for the treatment of pulmonary fibrosis: safety, lung deposition, and pharmacokinetic study Article 03 October 2020 Traditional Chinese medicine inspired dual-drugs loaded inhalable nano-therapeutics alleviated idiopathic pulmonary fibrosis by targeting...