The global incidence of lung cancer is decreasing in parallel with declining smoking rates in developed countries; however, the incidence of lung cancer in individuals who have never smoked (LCINS) is stable or increasing. LCINS is the eighth leading cause of cancer-related mortality in the USA...
Sarcomatoid transformation is a type of lung cancer histologic evolution with a poor prognosis and a high proportion of cases with aberrant MET activation and PD-L1 expression. 目标: 肺癌存在各种获得性耐药机制导致治疗失败或疾病进展,耐药...
Cough is present in 50 to 75% of patients with lung cancer.[2]Cough productive of large volumes of thin, mucoid secretions is seen in mucinous adenocarcinoma. In some cases, especially those with exophytic bronchial masses, a cough may signify secondary post-obstructive pneumonia. Hemoptysis is ...
Sarcomatoid lung carcinomas account for 0.1% to 0.3% of all lung cancer diagnoses. These malignancies often present at imaging as nonspecific peripherally located masses that may be associated with chest wall invasion. Sarcomatoid carcinomas are aggressive cancers associated with a poor prognosis. ...
The tumor also may manifest in a monophasic form of either epithelioid cancer resembling a pleural adenocarcinoma or a spindle sarcomatoid form resembling a mesenchymal sarcoma. The diagnosis is usually but not exclusively rendered with a history of asbestos exposure, similar to that for pleural ...
Pulmonary sarcomatoid carcinoma (PSC) is a rare subtype of lung cancer with poor prognosis. Here the authors performed multi-omics analysis of human samples to investigate the mutational landscape of PSC and show three subgroups of PSC with distinct biology, prognosis and potential therapeutic strategi...
LUNG CANCER CLASSIFICATION IN RESECTION SPECIMENS ADENOCARCINOMA SQUAMOUS CELL CARCINOMA LARGE CELL CARCINOMA NEUROENDOCRINE TUMORS SARCOMATOID CARCINOMA NUT CARCINOMA TUMORS OTHER THAN LUNG CANCER WITH SIGNIFICANT CHANGES FROM THE 2004 WHO CLASSIFICATION REFERENCESShow full outline Cited by (3343) Figures (7...
[1]lungcancerBecauselungcancerhistologicalphenotypecomplexclassificationmethodhaslongnotagree,perfectis1999bytheWHO(WHO)classification:dividedintosquamouscellcarcinoma,adenocarcinoma,adenosquamouscarcinoma,largecellcarcinoma,sarcomatoidcarcinomaandsmallcelllungcancer(SCLC)and6basictypes.Therearesignificantdifferencesbetweenthe...
SCLC small cell lung cancer TIMP3 tissue inhibitor of metalloproteinase 3 1. Introduction Lung cancer is one of the most prevalent malignancies and the leading cause of cancer-related death in the US and in China [1, 2]. Among patients with lung cancer, non-small cell lung cancer (NSCLC)...
Visual inspection of histopathology slides is one of the main methods used by pathologists to assess the stage, type and subtype of lung tumors. Adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC) are the most prevalent subtypes of lung cancer, and