Now halfway through my 6-cycle (once every three weeks) chemo treatment regimen. And I have my glow-in-the-dark PET scan scheduled for Feb 5th, the day before my birthday. We’ll see what that shows. And the week following that will be my 3rd Cancerversary Celebration. Lots happening....
PurposeSurgical resection remains the treatment of choice for patients with stage I non—small-cell lung cancer (NSCLC). However, there is high likelihood of medical comorbidity in this patient population, requiring management by nonsurgical approaches. We report our experience using conventional and ...
Metastasis can occur following surgical resection of solid tumors and metastasis is the main cause of cancer death. The role of anesthetics used during surgery in cancer metastasis and the underlying mechanism remains largely unknown. Here we show that surgical dissection of primary tumors in mice un...
Oncogenesis (2017), 1 – 11 MiR-34a as a tumor suppressor in lung cancer Y-L Li et al Illuminometer (Titertek-Berthold, South San Francisco, CA, USA). Relative activities were expressed as the fold-change in luciferase activity following normalization to renilla luciferase activity. A549 ...
Changes from baseline in exercise capacity and dyspnoea were assessed at Week 52 using 6-min walk distance (6MWD) and the University of California—San Diego Shortness of Breath Questionnaire (UCSD SOBQ) total score, respectively. Composite outcomes analysed over 52 weeks were: 6MWD decline ≥...
PD-1/PD-L1 immunotherapy resistance in NSCLC is described, e.g., as being attributed to the loss-of-function of IFN signaling and the resulting decrease in IFN-γ-induced PD-L1 expression in cancer cells [21]. The PD-L1 tumor proportion score (TPS) determined by immunohistochemistry (IHC...
Lung cancer is the leading cause of cancer-related mortality in the United States, accounting for over 150,000 deaths each year [1]. Unfortunately, even patients with early-stage non-small cell lung cancer (NSCLC) who undergo curative-intent therapy have a significant risk of recurrence, rangin...
We assessed dyspnea using the European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire Lung Cancer Module 13 (LC13) and functional EC using the 6-minute walk. We replicated results with the University of California San Diego Shortness of Breath Questionnaire. ...
Functions of miR-185 in the regulation of non-small cell lung cancer cell proliferation Since the association between miR-185 and poorer prognosis in patients with NSCLC was demonstrated, a series of functional assays was performed to evaluate the functions of miR-185 in the regulation of NSCLC ...
conducted an early proof-of-concept study showing that exosomes from human embryonic kidney cells could efficiently convey exogenous therapeutic let-7a in EGFR-expressing xenograft breast cancer tissues from RAG2(–/–) mice, leading to tumor regression [35]. Our method of collecting EVs has ...