Tumor heterogeneity and resistance to EGFR-targeted therapy in advanced nonsmall cell lung cancer: challenges and perspectives Xinghua Cheng, Haiquan ChenDepartment of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, Peoplersquo;s Republic of ChinaAbstract: Lung... H Chen,X Cheng...
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Robinson, L.A., Jaing, C.J., Campbell, C.P., Magliocco, A., Thissen, J.B and Antonia, S. (2016) Molecular evidence of viral DNA in non-small cell lung cancer and non-neoplastic lung. Br. J. Can., 115(4): 497-504.
Tumor heterogeneity and resistance to EGFR-targeted therapy in advanced nonsmall cell lung cancer: challenges and perspectives Xinghua Cheng, Haiquan ChenDepartment of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, Peoplersquo;s Republic of ChinaAbstract: Lung... H Chen,X Cheng...
In 1860, Armand Trousseau described the association between thrombotic events and cancer diagnosis, a phenomenon that became known as the “Trousseau sign” [3]. One of the consequences of this hypercoagulable status is the development of sterile thrombotic friable cardiac vegetations, which were ...
Since 2012, lung cancer screening with LDCT has been recommended by several countries around the world. Until 2016, three countries have enacted guidelines related to lung cancer screening, including China, the United States and Canada. However, in Hong Kong, primary prevention remains the fundamenta...
Kirsten rat sarcoma viral oncogene homologue (KRAS) gene mutations are among the most commonly found oncogenic alterations in non-small cell lung cancer (NSCLC) patients. Unfortunately, KRAS mutations have been considered “undruggable” for many years,
Altered mitochondrial function underlies the pathogenesis of both Alzheimer’s disease (AD) and cancer. Elevated mitochondrial respiration supports cancer development, while reduced levels contribute to AD. Lung cancer particularly depends on mitochondrial respiration. Heme, essential for mitochondrial ...
The advent of immune checkpoint inhibitors (ICIs) has revolutionized the treatment paradigm of lung cancer, resulting in notable enhancements in patient survival. Nevertheless, evaluating treatment response in patients undergoing immunotherapy poses distinct challenges due to unconventional response patterns like...