When Lewis first learned about the National Lung Screening Trial, she was excited about the potential to save lives through early lung cancer screening. However, after surveying her peers, she quickly realized that the wider medical community did not share her enthusiasm for implementing lung cancer...
An Example of an Indirect Exposure “Take Home” Lung Cancer Case Lung cancer claiming in asbestos litigation is not limited to persons who worked directly with asbestos. To the contrary, some family... Kirk Hartley May 28, 20151 min read 2 views 0 comments Post not marked as liked 1st An...
Patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC) often develop resistance to current standard third-generation EGFR tyrosine kinase inhibitors (TKIs); no targeted treatments are approved in the osimertinib-
If the majority of mutations derive from the me´lange of mutagens present in tobacco smoke, the clone of cells that ultimately becomes cancerous would acquire, over its lifetime, an average of one mutation for every 15 cigarettes smoked. If this is the case in a localized cluster of ...
Oxnard, MD JAMA Oncology Research Letter Genetic Alterations and Response to EGFR Tyrosine Kinase Inhibitors in Non–Small Cell Lung Cancer Shaodong Hong, MD; Fangfang Gao, MD; Sha Fu, MD; Yan Wang, PhD; Wenfeng Fang, MD, PhD; Yan Huang, MD; Li Zhang, MD JAMA Oncology From the JAMA ...
However, the relevance of these characteristics remains unclear for immunotherapy with blockade of the PD-1 pathway, and data from Chinese patients remain scarce. At the 14th Lung Cancer Summit, Chinese scientists introduced several proposals for immunotherapy using PD-1 or PD-L1 inhibitors. First,...
Non small cell lung cancer cell lines used in the study were obtained from ATCC. The cells were cultured in RPMI1640 media (Corning) containing FBS (Hyclone) at 10% v/v. Cells were maintained at 37°C in the presence of 5% CO2. Cells were passaged every 3 days. Human Non Small Cell...
To discuss the optimal treatment modality for inoperable locally advanced Non-Small Cell Lung Cancer patients with poor physical status, impaired cardio-pulmonary function, and negative driver genes, and provide clinical evidence. Materials and methods Retrospective analysis of 62 cases of locally advanced...
γδ T cells are a distinct subgroup of T cells that bridge the innate and adaptive immune system and can attack cancer cells in an MHC-unrestricted manner. Trials of adoptive γδ T cell transfer in solid tumors have had limited success. Here, we show t
Mutant selective EGFR kinase inhibitor (WZ4002) bound to EGFR containing the EGFR T790M Tarceva resistance mutation (purple area), which resides inside the EGFR protein (orange structure). Credit: Eric Smith, Dana-Farber Cancer Institute The ability to make, test, and map the atomic structure of...