The role of precision medicine in advanced non-small cell lung cancer (NSCLC) has been continuously increasing in the latest years. The path to achieve complete molecular information is certainly long and challenging, as it is affected by the evolving and ever-changing nature of the neoplastic ph...
1.3 Non-small cell lung cancer Although cigarette smoking is the chief causative agent of lung cancers, exposure to asbestos, radon, arsenic, chromium, vinyl chloride, and polycyclic aromatic hydrocarbons are also implicated as risk factors [2]. Adenocarcinomas (40%–50%), squamous cel...
Oxnard, MD JAMA Oncology Research Letter Genetic Alterations and Response to EGFR Tyrosine Kinase Inhibitors in Non–Small Cell Lung Cancer Shaodong Hong, MD; Fangfang Gao, MD; Sha Fu, MD; Yan Wang, PhD; Wenfeng Fang, MD, PhD; Yan Huang, MD; Li Zhang, MD JAMA Oncology From the JAMA ...
To discuss the optimal treatment modality for inoperable locally advanced Non-Small Cell Lung Cancer patients with poor physical status, impaired cardio-pulmonary function, and negative driver genes, and provide clinical evidence. Materials and methods Retrospective analysis of 62 cases of locally advanced...
γδ T cells are a distinct subgroup of T cells that bridge the innate and adaptive immune system and can attack cancer cells in an MHC-unrestricted manner. Trials of adoptive γδ T cell transfer in solid tumors have had limited success. Here, we show t
Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China; 2Department of Oncology, Shanghai Medical College, 3Institute of Pathology, Fudan University, Shanghai, People's Republic of China; 4Department of Pathology, Renji Hospital, School of Medicine, Shanghai Jiaotong Universi...
Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China; 2Department of Oncology, Shanghai Medical College, 3Institute of Pathology, Fudan University, Shanghai, People's Republic of China; 4Department of Pathology, Renji Hospital, School of Medicine, Shanghai Jiaotong Universi...
ACRIDINE orangeNon‐small–cell lung cancer (NSCLC) is one of the most prevalent type of lung cancers with an increased mortality rate in both developed and developing countries worldwide. Dieckol is one such polyphenolic drug extracted from brown algae which has proven antioxidant and anti‐...
Recently, a panel of experts proposed a major revision of the lung cancer classification system.143 These changes primarily affect the classification of adenocarcinoma and its distinction from squamous cell carcinomas (Table 1).143 The new classification system from the International Association for the...
In this study, the impact of the apolipoprotein B mRNA-editing catalytic subunit-like (APOBEC) enzyme APOBEC3B (A3B) on epidermal growth factor receptor (EGFR)-driven lung cancer was assessed. A3B expression in EGFR mutant (EGFRmut) non-small-cell lung c