Background and clinical significance of biomarker-based patient enrichment in non-small-cell lung cancer drug development Article Open access 26 March 2024 The National Lung Matrix Trial of personalized therapy in lung cancer Article 15 July 2020 Development and validation of a decision model fo...
Background The standard treatment of stage III N2 small cell lung cancer (SCLC) is concurrent chemoradiation, and surgery is not recommended. This study was aimed to evaluate whether surgery has survival benefits in patients with stage III N2 SCLC and investigate the factors influencing survival of...
risk factorstrendChina is faced with heavy burdens caused by lung cancer,which has climbed to the top of both cancer incidence and mortality spectrums.The age-standardized rates of incidence and mortality have shown a trend of gradual uptrends in the last decades,while the crude rates rise much...
Lung cancer is the leading cause of cancer-related death worldwide1. Cancer risk factors include intrinsic and non-intrinsic factors. The majority of cancer risk factors (60–90%) are non-intrinsic2,3. Intrinsic risk has been defined as intrinsic DNA replication errors which are unmodifiable and...
Background Several targeted immunotherapies have recently showed significant advances in treatment of non-small cell lung cancer (NSCLC), including antibodies and inhibitors targeting programmed death-1 (PD-1) and its ligand (PD-L1). Methods Tumor tissue samples were prospectively collected from 183 ...
Background Light at night (LAN) has become a concern in interdisciplinary research in recent years. This global interdisciplinary study aimed to explore the exposure–lag–response association between LAN exposure and lung cancer incidence. Methods ...
Xuanwei City (formerly known as Xuanwei County) locates in the northeastern of Yunnan Province and is rich in coal, iron, copper and other mines, especially the smoky (bituminous) coal. Unfortunately, the lung cancer morbidity and mortality rates in this region are among China's highest, with...
Background The purpose of this study was to identify risk factors for disease recurrence and unfavorable prognosis after surgical resection for stage I non-small cell lung cancer in patients with tumor diameters of ≤20 mm. Methods One hundred sixty-three patients who had pathologic stage I non-...
Background In the past few decades, systemic treatment for lung cancer remained to be cytoxicity agents with platinum-based regimens. ECOG1594 was the first trial comparing four different chemotherapy regimens for advanced non-small cell lung cancer (NSCLC) head to head [1]. All chemotherapy regi...
Background: Uncontrolled proliferation is a hallmark of malignant tumour growth. Its prognostic role in non-small cell lung cancer (NSCLC) has been investigated in numerous studies with controversial results. We aimed to resolve these controversies by assessing the Ki-67 proliferation index (PI) in...