In compromised hosts, the bacterial causes of pneumonia are much broader, including species not usually considered of high virulence in humans. Indeed infection with one of these unusual bacterial species demands a search for an immunocompromising condition. Normal defences of the respiratory tract ...
Sepsisdescribes a complex clinical syndrome occurring as a result of a systemic inflammatory response to live bacteria or bacterial products. Sepsis develops when the initial, appropriate host response to an infection becomes amplified and is then deregulated. According to the current definition, sepsis...
Although 4T1 mammary carcinoma cell line is a highly tumorigenic and invasive cell line and can spontaneously metastasize from the mammary gland to the lung, our results indicated that chronic bacterial infection accelerated this process. To confirm whether the alteration of the premetastatic niche cau...
A fungus that causes a rapidly disseminating and potentially fatal infection in the lungs. Antibiotic Resistance Genes mecA (incl MRSA) A gene found in bacterial cells which allows them to be resistant to antibiotics such as methicillin, penicillin and other penicillin-like antibiotics. ...
, neutrophil elastase activity normalized using neutrophil numbers was significantly lower in SPLUNC1−/− mice compared with littermate control mice (Figure 4D), which indicates that SPLUNC1 is important for stimulation of neutrophil elastase activity during the course of lung bacterial infection....
Chronic infection and consequent airway inflammation are the leading causes of morbidity and early mortality for people living with cystic fibrosis (CF). However, lower airway infections across a range of chronic respiratory diseases, including in CF, do not follow classical ‘one microbe, one diseas...
One particularly challenging infection occurs when biofilms grow on the surface of endotracheal tubes used by critically-ill patients who require mechanical ventilators to breathe. This causes ventilator-associated pneumonia (VAP), a condition that affects one in four (9–27%)...
Lung emphysema and chronic bronchitis are the two most common causes of chronic obstructive pulmonary disease. Excess macrophage elastase MMP-12, which is predominantly secreted from alveolar macrophages, is known to mediate the development of lung injur
Symptoms depend on whether the abscess is caused by anaerobic or other bacterial infection. A lung abscess may be asymptomatic in a small proportion of patients in the early stages. Typical symptoms are below. Anaerobic infection in lung abscess Patients often present with indolent symptoms that evo...
Spectrum of Aspergillus infection lung transplant recipients: case series and review of the literature Chest, 119 (1) (2001), pp. 169-175 View PDFView articleView in ScopusGoogle Scholar [24] T. Franquet, N.L. Müller, A. Giménez, S. Martínez, M. Madrid, P. Domingo Infectious pulmon...