Targeted (nano-)drug delivery is essential for treating respiratory diseases, which are often confined to distinct lung regions. However, spatio-temporal profiling of drugs or nanoparticles (NPs) and their interactions with lung macrophages remains unresolved. Here, we present LungVis 1.0, an AI-pow...
pleuraPractical, unbiased stereological methods are described to estimate lung volume and external surface area, and total volume and surface area of relatively large and anisotropic structures (bronchi and arteries) inside the lung.The volume of each of five lung strata was estimated first by fluid...
However, the past two scans have shown slight changes in the pleura and lower lobe of my right lung. It’s unclear if these lung changes mean progression but there is reason for concern. On a good note, the slowness of this train means that my brilliant care team has the luxury of tim...
Pancoast syndrome: Mostly due to NSCLC Apical tumors invade the brachial plexus , pleura , or ribs resulting in: Shoulder and upper extremity pain Upper extremity weakness Atrophy of the ipsilateral hand Horner’s syndrome: ptosis , miosis , anhidrosisPericardial spread: ...
S1B), and computed tomography (CT) revealed peripheral consolidation and nodular opacification; bilateral, irregular, thin-walled cysts along pleura and interlobar septa with upper lobe predominance and central sparing; and age-dependent progression in cyst number and size (Figures 1F, 1G, and S1C...
CT better assesses tumor size, invasion of the pleura and mediastinum, and distance of the tumor from the carina. Also, abnormalities such as atelectasis and aspiration pneumonia can cause abnormal F-18 FDG uptake that may be confused with that of the primary tumor are often clear on CT. ...
of “proximal” lung and breast or “distal” gastrointestinal and ovary cancers as well as lymphoma (3). Metastasis is singlehandedly the gravest outcome for a tumor in terms of patient survival. Additionally, metastasis to the pleura may lead to a troublesome complication, malignant pleural ...
lung, in air-breathing vertebrates, either of the two large organs ofrespirationlocated in thechest cavityand responsible for addingoxygento and removingcarbon dioxidefrom the blood. In humans each lung is encased in a thin membranous sac called thepleura, and each is connected with thetrachea(wi...
Lung anatomy Lung lobes By the end of gestation, five well-defined lung lobes are present, three on the right (upper, middle, and lower lobes) and two on the left (upper and lower lobes).3,6,7 Each of the five primary lobar buds is invested with visceral pleura. Each lobe in turn...
The root of the lung, on the other hand, consists of these structures themselves – the bronchi, arteries, veins, and nerves – bundled together with connective tissue. It is this collection of structures, covered by pleura, that forms a bridge between the lung and the mediastinum, providing...