European Journal of Pharmaceutics and Biopharmaceutics Lubrication in tablet formulationsWang, JenniferWen, HongDesai, Divyakant
Lubrication of 2:1 and 1:1 blends of microcrystalline cellulose and spray-dried lactose or dibasic calcium phosphate (DCP) with 0.33% or 1% magnesium stearate, as model free-flowing pharmaceutical formulations, was performed in rotary drum blenders. Blender process parameters examined in this study...
Strength: 5mg per ml in 2ml Ampoule /5mg/10mg per Tablet Contact us for more information Product Gelucire 59/14 Gelucire® 59/14 is a mixture of lauroyl PEG-32 glycerides and PEG 6000 and has surfactant properties. It is a self-emulsifying excipient used for oral bioavailability enhanceme...
The observed results could be correlated to the wall friction angle, compaction properties and tablet brittleness index of the raw materials and blends. This study showed the potential of external lubrication as an alternative lubrication method for lubricant-sensitive formulations....
In-silicoModelLubricationTensile strengthCompression pressureA new approach is proposed to support prediction of tablet tensile strength as a function of both solid fraction (and/or compression pressure) and extent of lubrication by using empirical data to parameterise the model. This is a pre-...
It has been shown repeatedly that incorporation of partially pre-gelatinized maize starch (Starch 1500~(TM)) markedly reduces sticking, binding and ejection forces of direct compression formulations in tablet punch and dies. The origins of the self-lubrication properties of Starch 1500~(TM) seem ...
It has been shown repeatedly that incorporation of partially pre-gelatinized maizestarch (Starch 1500TM) markedly reduces sticking, binding and ejection forces ofdirect compression formulations in tablet punch and dies.The origins of the self-lubrication properties of Starch 1500TM seem to lie in its...
TabletModelLubrication of 2:1 and 1:1 blends of microcrystalline cellulose and spray-dried lactose or dibasic calcium phosphate (DCP) with 0.33% or 1% magnesium stearate, as model free-flowing pharmaceutical formulations, was performed in rotary drum blenders. Blender process parameters examined in ...
It has been shown repeatedly that incorporation of partially pre-gelatinized maizestarch (Starch 1500TM) markedly reduces sticking, binding and ejection forces ofdirect compression formulations in tablet punch and dies.The origins of the self-lubrication properties of Starch 15...