吸烟是肺癌的高危因素,约有80%的肺癌与吸烟有关,其中LUSC与吸烟关系更为密切;不吸烟的肺癌患者以LUAD、女性和东亚人群为主,其病因与二手烟、环境污染、职业致癌物等环境因素和遗传易感性有关。 LUAD和LUSC虽均属于NSCLC,但从无论从临床表现、生物学特性...
肺癌在组织学上分为小细胞肺癌(SCLC)和非小细胞肺癌(NSCLC),后者约占总病例的85%。肺腺癌(LUAD)和肺鳞状细胞癌(LUSC)是NSCLC最常见的两种亚型。 肺腺癌病因 肺部是人体最重要的气体交换场所,肺泡中密布毛细血管,排出二氧化碳,摄入氧气。肺部的组织细胞如果...
Besides, LUSC was correlated with fewer M2 tumor-associated macrophages (TAMs) and PD-1+ immune cells (p < 0.001; p = 0.02), while no significant differences were found in tumor-infiltrating FOXP3+ cells (p = 0.41) and B lymphocytes (p = 0.61). In addition, natural killer cells were...
High frequency of γδT cells was observed in patients with LUAD and LUSC, whereas the levels of CD4 + T cells, CD8 + T cells and CD56 + cells were decreased. Elevated γδT cells in tumors were mainly IL-17A-releasing γδT17 cells, which were found to be enriched ...
High ECT2 expression is an independent prognostic factor for poor overall survival and recurrence-free survival in non-small cell lung adenocarcinoma In addition, we also investigated the enrichment of ECT2 co-expressed genes in KEGG pathways in LUAD and LUSC. Bioinformatic analysis was performed ...
Lung cancer is the second most common malignant tumor after breast cancer and the leading cause of cancer-related death worldwide [1]. Due to the reduction in tobacco smoking, the incidence of lung squamous cell carcinoma (LUSC) had decreased, while the incidence of lung adenocarcinoma (LUAD)...
The value of CEP55 gene as a diagnostic biomarker and independent prognostic factor in LUAD and LUSC PLoS ONE, 15 (2020), p. e0233283 CrossrefView in ScopusGoogle Scholar 24 F. Fazi, A. Fatica Interplay Between N6-Methyladenosine (m6A) and Non-coding RNAs in Cell Development and Cancer...
Results: Only 5 ISs were identified in the TCGA NSCLC cohort; the proportion of the C3 inflammatory IS (39.2%) was the most common IS observed in the TCGA LUAD cohort, whereas C1 was particularly dominant in LUSC (57.1%). The proportion of C3 was also the most common IS observed in ...
肺癌作为最常被诊断的癌症,是全球范围内癌症相关死亡的主要原因之一。肺癌在组织学上分为小细胞肺癌(SCLC)和非小细胞肺癌(NSCLC),后者约占总病例的85%。肺腺癌(LUAD)和肺鳞状细胞癌(LUSC)是NSCLC最常见的两种亚型。 肺腺癌病因 肺部是人体最重要的气体交换场所,肺泡中密布毛细血管,排出二氧化碳,摄入氧气。肺部的组...
For tiles associated with LUSC, we note a predominance of areas of keratinization and dyskeratotic cells as well as rare foci of cells with prominent intracellular bridging. Among the tiles denoted LUAD, the predominant feature noted is the presence of distinct gland forming histological patterns,...