LT-HSCs from AhR-KO mice display alterations in gene expression: LT-HSCs from aged AhR-KO and WT mice were sorted and analyzed for changes in gene expression using qPCR.John, A. BennettKameshwar, P. SinghZeenath, Unni...
miRNA expression in LT-HSCs upon Thrombopoietin stimulation via STAT5Rieger, MichaelFeuermann, YonatanHaetscher, Nadine
LRF loss at HSC/progenitor levels led to excessive differentiation of HSCs into T cells in the BM at the expense of B cell development. Concomitantly, the numbers of LT-HSCs (CD34CD150+CD48Flt3IL7R伪LinSca-1+c-Kit+) were significantly reduced in LRFflox/floxMx1-Cre+ mice one month ...
Npm1ca Overcomes the Differentiation Block of DNMT3A-Mutant LT-HSCs to Transition MDS to Myeloproliferative Disorderdoi:10.1016/j.exphem.2018.06.165Jennifer TrowbridgeMatthew LobergRebecca BellTim StearnsLeslie GoodwinKira YoungDavid BergstromRebekka Schneider...
The CD150high compartment is not the exclusive reservoir of LT-HSCs within the bone marrow. Blood. 2008; 111 :4414–5.Chambers S.M., Weksberg D.C., Goodell M.A. 2008. Response: The CD150high compartment is not the exclusive reservoir of LT-HSCs within the bone marrow...
Aging alone changes gene expression in LT-HSCs.John, A. BennettKameshwar, P. SinghZeenath, UnnisaStephen, L. WelleThomas, A. Gasiewicz
LT-HSC marker expression is altered on Runx1 deficient HSCs.Xiongwei, Cai
Angptl3 augments the expansion of LT-HSCs from LSK cells.Elnaz, FarahbakhshianMonique, M. VerstegenTrudi, P. VisserSima, KheradmandkiaDirk, GeertsShazia, ArshadNoveen, RiazFrank, GrosveldNiek, P. van TilJules, P. P. Meijerink
qPCR validated gene changes dependent on lack of AhR and aging in LT-HSCs of AhR-KO mice are related to cell-proliferation, trafficking and HSC function and have functional overlap with AhR.John, ...
Selected genes related to Hematological System Development and Function found to be altered in LT-HSCs of aged AhR-KO mice.John, A. BennettKameshwar, P. SinghZeenath, UnnisaStephen, L. WelleThomas, A. Gasiewicz