Both studies were approved by the Ethics Committee for Northwest/Central Switzerland and by the Federal Office of Public Health. All participants provided written consent and received monetary compensation. Experimental procedure Participants were administered 100 μg LSD orally in capsules (trial A) ...
Finally, we confirmed these results in a more clinically relevant context, using T cells derived from pmel-1 TCR–Tg mice and specific for the self/tumor antigen gp100, which has been targeted also in human clinical trials47. Pmel-1 CTL were first skewed ex vivo towards a memory phenotype...
It happened on a May morning—I have forgotten the year—but I can still point to the exact spot where it occurred, on a forest path on Martinsberg above Baden, Switzerland. As I strolled through the freshly greened woods filled with bird song and lit up by the morning sun, all at ...
The study was approved by the Ethics Committee for Northwest/Central Switzerland (EKNZ) and by the Federal Office of Public Health. All subjects provided written consent prior to participating and received monetary compensation. This study was registered at clinicaltrials.gov prior to study start (...
In 1949 Rinkel, a research psychiatrist, obtained a supply of LSD from Sandoz Pharmaceuticals in Switzerland and gave the drug to his partner, Dr Robert Hyde, who took the first acid trip in the Western Hemisphere. Rinkel and Hyde went on to organize an LSD study at the Boston Psychopathic...
The studies were conducted in accordance with the Declaration of Helsinki and approved by the local ethics committee. The administration of LSD to healthy subjects was authorized by the Swiss Federal Office for Public Health, Bern, Switzerland. All of the subjects provided written consent before ...
The use of LSD was authorized by the Swiss Federal Office for Public Health (Bundesamt für Gesundheit), Bern, Switzerland. Written informed consent was obtained from all of the subjects. All of the subjects were paid for their participation. The washout periods between doses were 7 days for ...
To date, several epigenome-targeting drugs have been approved or are currently under clinical trials, including inhibitors of DNA methyltransferases (DNMTi) and histone deacetylase (HDACi) [8]. However, different epigenetic inhibitors generated unwanted effects, and acquired resistance to epi-drugs is...
Breast cancer is the leading cause of cancer death in the female population, despite advances in diagnosis and treatment. The highly heterogeneous nature of the disease represents a major obstacle to successful therapy and results in a significant number