To the best of our knowledge, this is the first study to examine the impact of LSD on whole-brain EC. We found that compared to placebo, LSD impacted local gain and was associated with primarily stronger FC and
reveal what happens in the brain when people experience the complex visual hallucinations that are often associated with LSD state. They also shed light on thebrain changesthat underlie the profound altered state of consciousness the drug can produce. ...
Nevertheless, it has been shown that major life events with high personal significance, including experiences engendered by psychedelic drugs, can have an enduring impact on some core facets of personality. In the present, balanced-order, placebo-controlled study, we investigated biological predictors ...
However, most studies focus on the psychological aspect of using music in psyche- delic therapy, rather than investigate its impact on the brain network organization and fluctuations of brain activity in time. As a result, brain activity under music and psychedelic influence remains poorly understood...
there were no significant changes in the dwell times under psilocybin, but there were significant increases in the appearance rates of two of the states (Fig.3c). Possibly, this highlights a subtle difference in the two compounds’ impact on brain dynamics or a difference in dynamics under drug...
Jerome, who is visually impaired herself, said she is unconvinced that having a visual impairment provides any special insight on how LSD alters sensory processes. "But it might provide greater motivation or interest in the sensory impact of psychedelic compounds," she told Live Science. ...
“It’s a sign of the times,” says Diane. “LSD is a very flexible substance. It amplifies whatever is happening in your brain. It is amplifying whatever is happening in our society. We are all productivity-obsessed, so that’s our usage of it.” Silicon Valley’s microdosers want to...
The psychic effects of LSD, which are produced by such minimal quantities of material, are too meaningful and too multiform to be explained by toxic alterations of brain function. If LSD acted only through a toxic effect on the brain, then LSD experiences would be entirely psychopathological in...
To investigate this possibility, the main effect of all networks was assessed by simultaneously including all ten networks as seeds and calculating a weighted contrast (reflecting the common effect of these seeds on voxels covering the whole brain; cluster threshold p < 0.05, FDR, cluster-...
We therefore used the music conditions with placebo and LSD in order to increase the impact on the serotonin system (see Figure 3, and we also confirmed the results for the non-music condition [Figure S1]). Specifically, the model was first fitted to the placebo condition, and subsequently,...