Although it is commonly stated that phencyclidine is an antagonist at ionotropic glutamate receptors, there has been little measure of its potency on other... P Seeman,HC Guan,H Hirbec - 《Synapse》 被引量: 113发表: 2010年 Pharmacological characterization of a serotonin receptor (5-HT7) stimu...
Much of the research on hallucinogenic drugs such as LSD has focused on the neurotransmitter serotonin, a chemical that when released from a presynaptic serotonin-secreting neuron causes the transmission of a nerve impulse across a synapse to an adjacent postsynaptic, or target, neuron. There are ...
mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists. Science. 2010;329:959–64. Article CAS PubMed PubMed Central Google Scholar Santarelli L, Saxe M, Gross C, Surget A, Battaglia F, Dulawa S, et al. Requirement of hippocampal neurogenesis for the ...
Possible effects of LSD on dopamine D2/3 receptor availability have not previously been investigated in living brain. Therefore, we used PET to map the binding potential (pB) of [11C]raclopride in brain of three pigs, first in a baseline condition, and again at 1 and 4 h after ...
However, analyzing the PSD enriched fraction, while some of these proteins were consistently reduced also at the PSD level, we found that some others increased their levels locally at the synapse. In further detail, PSD-95, an index of post-synaptic integrity and activity and similarly, the ...
What are the effects of drugs in neurotransmitters? How is a neurotransmitter released? (a) What is a synapse? (b) What is a neurotransmitter? What is the relationship between action potentials and neurotransmitter release? Is acetylcholine the only neurotransmitter or there are others? Explain. ...
The chief therapeutic limitation of LSD and other psychedelics is their behavioral liability and psychoactivity. This liability is dose-dependent, however, and anti-inflammatory effects associated with psychedelics may be therapeutically applicable at sub-perceptual doses in humans as they are in animal...
Given the profound effects of Rcor2 on cortical development, we examined the proliferation and neurogenesis capacities of NSCs/NPCs on Rcor2 depletion during cortical development. Compared with the control group, decreased expressions of NPC markers Sox2 and Nestin were observed by immunostaining in ...
Much of the research on hallucinogenic drugs such as LSD has focused on the neurotransmitter serotonin, a chemical that when released from a presynaptic serotonin-secreting neuron causes the transmission of a nerve impulse across a synapse to an adjacent postsynaptic, or target, neuron. There are ...
P Seeman,HC Guan,H Hirbec - 《Synapse》 被引量: 113发表: 2010年 Distinct temporal phases in the behavioral pharmacology of LSD: dopamine D2 receptor-mediated effects in the rat and implications for psychosis. Rationale The effect of LSD in humans has been described as occurring in two tempo...