Nuclear receptors are the largest members of the transcription factor family,which regulate the expression of target genes in a ligand dependent manner,and participate in the regulation of metabolism,development and reproduc-tive function of the body.LRH-1 (Liver receptor homolog-1 ),also known as...
However, the effects of LRH-1 on reproductive function of poultry, especially on nest individuals, have not been reported. Therefore, it is of great significance to study the regulation of LRH-1 on reproductive performance of poultry. Sichuan Mountainous Black-bone Chicken (yellow feather line) ...
BL001 protects human islet from apoptosis improving function Having validated the proof-of-concept in mice that BL001 protects islets and prevents both chemically and autoimmune-induced diabetes, we next sought to determine whether these beneficial effects were translated to human islets under stress co...
Here we investigate the physiological and pathophysiological function of hLRH-1 in the intestinal epithelium. Using humanized mouse intestinal organoids, a humanized in vivo IBD model, and human intestinal organoids, we uncover an essential role for LRH-1 in intestinal epithelial homeostasis and cell...
We characterized a domain in its hinge region that imposes a strong repression on the transcriptional activity of hB1F, which is important for the function of hB1F on regulating the activity of HBV enhancer II/core promoter. Mutations of the core residues in this domain abrogate the...
In the present study, we performed transcription activator-like effector nuclease (TALEN)-mediated loss-of-function assays, taking advantage of zebrafish external fertilization, to investigate the function of lrh-1. The digestive organs were affected by lrh-1 depletion as a result of cell-cycle ...
More recently, liver receptor homolog-1 has emerged as a key regulator of intestinal function, coordinating unanticipated actions, such as cell renewal and local immune function with important implications to common intestinal diseases, including colorectal cancer and inflammatory bowel disease. Unlike ...
This DNA binding-independent function of LRH-1, in addition to the classical DNA-dependent regulatory features of LRH-1, indicates a dual role for LRH-1 in transcriptional regulation, acting both as a DNA binding transcription factor, as is the case for cyclin E1 and SHP transcription, and ...
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Despite the growing knowledge with regard to the biological function of LRH-1, little is known about how LRH-1 is controlled at the transcriptional level. We identified STAT6 as a transcrip- tional regulator of LRH-1. This was evidenced by the induction of LRH-1 promoter activity by ...