TGF-β1免疫组织化学目的探讨富亮氨酸α2糖蛋白1(leucine-rich alpha-2-glycoprotein 1,LRG1)及转化生长因子beta 1(transforming growth factor-beta 1,TGF-β1)在膀胱尿路上皮癌(bladder urothelial carcinoma,BUC)组织中的表达及意义.方法采用免疫组化SP法检测LRG1,TGF-β1及Ki-67在64例BUC组织及25例癌旁...
内容提示: 膀胱尿路上皮癌中 LRG1和TGFβ1的表达及临床病理意义陈 龙1,2 ,张倩1,2 ,徐春明 1,2 ,蔡菁菁 3 ,张红霞 1,2 ,刘雨清 1 ,孙永红 3 ,丁小娣 1摘要:目的 探讨富亮氨酸 α2糖蛋白 1(leucinerichalpha2glycoprotein1,LRG1)及转化生长因子 beta1(transforminggrowthfactorbeta1,TGFβ1)在膀胱...
Accelerated re-epithelialization in beta3-integrin-deficient- mice is associated with enhanced TGF-beta1 signaling Nat Med, 11 (2005), pp. 167-174 CrossrefView in ScopusGoogle Scholar Reynolds et al., 2008 L.E. Reynolds, F.J. Conti, R. Silva, S.D. Robinson, V. Iyer, R. Rudling, ...
富亮氨酸α2糖蛋白1(LRG1)是一种蛋白质,是由基因LRG1编码的。包括LRG1在内的富含亮氨酸的重复(LRR)家族蛋白已被证明参与了蛋白质与蛋白质的相互作用、信号转导、细胞粘附和发育。LRG1在粒细胞分化过程中表达。LRG1通过引起内皮细胞中转化生长因子β(TGFbeta)信号的转换,参与促进新生血管(新血管生长)。LRG1与...
pathogenic role and whether it can be used as a diagnostic biomarker or therapeutic target. Despite gaps in our understanding of its biology, it is now clear that one of its main modes of action is in modulating transforming growth-factor β (TGFβ) signalling and as such it plays pivotal ...
LRG1 modulates invasion and migration of glioma cell lines through TGF-beta signaling pathway. Acta Histoch. 2015; 117(6):551–8. 21. Furukawa K, Kawamoto K, Eguchi H, et al. Clinicopathological significance of leucine-rich alpha2-Glycoprotein-1 in sera of patients with pancreatic Cancer. ...
E-cadherin是阻滞EMT发生的主要分子之一,LRG1是TGF-β的上游调节因子,本组实验结果显示,在胃癌组织中LRG1与E-cadherin的表达呈负相关(P<0.05),低分化胃癌组织中LRG1高表达,而E-cadherin表达缺失,作者推测LRG1通过TGF-β信号通路下调E-cadherin,诱导EMT的发生,促进胃癌细胞浸润性生长。关于其机制,研究认为TGF-β1...
However, few researches have been conducted to expose the integrated role of miR-497, leucine-rich alpha-2-glycoprotein-1 (LRG1) and transforming growth factor beta 1 (TGF-β1)/Smads signalling pathway in osteoporosis. Thereafter, the study is set out to delve into miR-497/LRG1/TGF-β1/...
Our findings suggest that the regulation ofLrg1by PPARβ/δ in fibroblasts is an important signaling conduit integrating PPARβ/δ and TGFβ1-signaling networks in skin health and disease. Thus, the FSPCre-Pparb/d−/−mouse model could serve as a novel tool in the current gunnery of ...
Host / Isotype Rabbit / IgG Reactivity human, mouseand More (1) Applications WB, IHC, IF, ELISA Conjugate Unconjugated Publications 31 Review Product Cat no :13224-1-AP Synonyms HMFT1766, LRG, LRG1 Print datasheet MSDS -/- Cat No.13224-1-AP ...