Moreover, siRNA-mediated inhibition of Fzd10 prevented TGF-尾1-induced myofibroblast differentiation of LR-MSCs in vitro and impaired bleomycin-induced pulmonary fibrosis. We conclude that hedgehog and Wnt/尾-cat
Moreover, siRNA-mediated inhibition of Fzd10 prevented TGF-尾1-induced myofibroblast differentiation of LR-MSCs in vitro and impaired bleomycin-induced pulmonary fibrosis. We conclude that hedgehog and Wnt/尾-catenin signaling play a critical role in promoting myofibroblast differentiation of LR-MSCs ...
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In addition, we discovered that TNF-α promotes myofibroblast differentiation of LR-MSCs through activating NF-κB signaling. Interestingly, we also found that TNF-α promotes the expression of β-catenin. Moreover, we demonstrated that suppression of the NF-κB signaling could attenuate myofibroblast...
The role of miR-497-5p in myofibroblast differentiation of LR- MSCs and pulmonary fibrogenesis. Sci. Rep. 7, 40958 (2017).Chen X, Shi C, Wang C, Liu W, Chu Y, Xiang Z, Hu K, Dong P, Han X. The role of...
www.nature.com/scientificreports OPEN The role of miR-497-5p in myofibroblast differentiation of LR-MSCs and pulmonary fibrogenesis received: 24 August 2016 accepted: 13 December 2016 Published: 18 January 2017 Xiang Chen1,2, Chaowen Shi1,2, Cong Wang1,2, Weilin Liu1,2,Yanhong ...