LPS 或脓毒症触发由小鼠血窦内 β2-整合素依赖性血小板-中性粒细胞相互作用介导的血管内 NET 发育。此外,中性粒细胞-内皮细胞相互作用和 NETs 在脓毒症大鼠模型中诱导微血栓形成和血管渗漏。NK细胞在肝脏中比在循环中丰富得多;具有几个不同亚群的 NKT 细胞有助于抗菌防御,并受肠道微生物群的影响。NK 和 NKT ...
最新研究发现中性粒细胞胞外诱捕网(Neutrophil extracellular traps,NETs)在脓毒症的病理生理过程中起着至关重要的作用,适量的NETs通过诱捕并消灭病原体对机体起到保护性作用,而脓毒症中过量的NETs则会引起靶器官损害,甚至导致全身器官功能障碍.甘草甜素(Glycyrrhizin,GL)是一种从甘草中提取的活性成分,具有抗炎,抗...
过度炎症反应是脓毒症期间凝血功能障碍的诱因,但免疫和凝血系统之间相互作用的关系目前还不清楚。 长久以来,中性粒细胞被认为是脓毒症中的主要效应细胞。中性粒细胞释放的蛋白水解酶和NETs等与患者的组织损伤程度呈现正相关。然而,在脓毒...
弥散性血管内凝血(DIC)是脓毒症的一种并发症,目前缺乏有效的治疗方式。中性粒细胞是脓毒症的主要效应细胞,可以释放蛋白酶、氧自由基和NETs加剧组织损伤;然而,在动物脓毒症模型中耗竭中性粒细胞反而加重了LPS诱导的败血症,表明中性粒细胞的...
结果:Lipopolysaccharides 处理后 H3-cit 和 TLR4 的表达增加。Lipopolysaccharides 诱导中性粒细胞胞外诱捕网 NETs 的形成。[3] 体内活性 方法:为构建败血症小鼠模型,将 Lipopolysaccharides (25 mg/kg) 单次腹腔注射给 C57/BL 小鼠。 结果:Lipopolysaccharides 诱导炎症因子 TNF-α 和 IL-1β 显著上调。Lipopolysaccha...
中晚期患者ESCC癌组织中存在NETs,较正常癌旁组织明显升高.2.血清中NETs水平在中晚期食管鳞癌,食管炎,食管早癌和健康人群中呈逐渐下降趋势.3.P.g-LPS促进食管上皮细胞和食管癌细胞迁移,并促进迁移相关基因RAC1m RNA的表达.P.g-LPS抑制食管上皮细胞增殖及增殖相关基因EGFR m RNA的表达,P.g-LPS促进食管癌细胞...
SP-D attenuates LPS-induced formation of human neutrophil extracellular traps (NETs), protecting pulmonary surfactant inactivation by NETsNeutrophilsTranslational researchImmune cell deathDot blots showing that SP-D binds to LPS. LPS (O128:B12) at different concentrations was dotted onto a membrane, ...
Post-processing or additional modules are required to handle the conflicts between the outputs from these two nets, which makes such methods suffer from low efficiency, heavy memory consumption and complicated implementation. To simplify the pipeline and decrease computation/memory cost, we propose an ...
such as scaffold sheeting, wall/side sheets, temporary roof sheets and covers normally supplied in rolls or tarpaulins, debris netting and meshes and twin wall/fluted sheet materials used externally on construction sites. The performance requirements are intended to ensure that containment nets and sh...
The noncanonical inflammasome is also functional in neutrophils, the activation of which triggers pyroptosis and neutrophil extracellular traps (NETs) formation in vitro (Chen et al., 2018). Our data provide genetic evidence that neutrophil-intrinsic sensing of intracellular LPS is vital for bacterial...