目的:探讨Nur77调控NETosis在脂多糖(LPS)所致急性呼吸窘迫综合征(ARDS)小鼠肺损伤中的作用.方法:(1)将16只野生型(Wild Type,WT)C57BL/6J小鼠以及16只Nur77基因敲除(Nur77-/-)小鼠按随机区组设计的原则分配至4组,分别为WT+NS组,WT+LPS组,Nur77-/-+NS组,Nur77-/-+LPS组,每组8只,通过气道内滴注LPS(...
LPS at concentrations of ≥5μg/mL induced substantial amount of NETosis. SP-D dose-dependently suppresses LPS (5μg/mL)-induced NETosis ( =3, the values shown are the average from three individual experiments performed on different days; Two-way ANOVA with Bonferroni's multiple comparison ...
Nevertheless, the molecular rheostats that regulate NETosis in response to bacteria are not clearly established. We hypothesized that stress-activated protein kinase or c-Jun N-terminal Kinase (SAPK/JNK) is a molecular switch that turns on NETosis in response to increasing concentrations of ...
Secondly, Pf increased anti-inflammatory IL-1RA and reduced neutrophil degranulation, phagocytosis, and NETosis. Thirdly, Pf affected downstream signaling kinases which might directly or indirectly influence neutrophil responses to LPS. In conclusion, the results suggest that Pf lessens the inflammatory ...
Gallic acidNeutrophilsROSNETosisApoptosisApoptosis and NETosis of neutrophils are two majordoi:10.1016/j.tiv.2015.10.005Toxicology in vitro: an international journal published in association with BIBRAHaute, G.V.; Caberlon, E.; Squizani, E.; Mesquita, F.C.; Pedrazza, L.; Martha, B.A.; ...