在体内实验中,研究人员通过腹腔注射单钠尿酸盐(MSU)晶体诱导小鼠腹膜炎模型,发现 ND6P25L小鼠的中性粒细胞浸润减少,这进一步证明了 mtROS 通过 RET 产生的过程在体内对 NLRP3 炎性小体激活的调节作用。 总的来说,这项研究详细地揭示了 LPS 刺激后巨噬细胞代谢重编程的时间进程,明确了 mtROS 是由复合物 I 处...
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are mainly responsible for hypoxic respiratory failure in adults with high morbidity and mortality during hospitalization [1]. ALI is characterized by the diffused lung inflammation, damage of lung epithelial barrier, and pulmonary ...
The results showed that CDN also blocked caspase-1 cleavage and IL-1β secretion triggered by ATP, MSU and poly(I:C) but had no effects on TNF-α production (Fig. 2F–I, Fig. 3A, C–E and Supporting Information Fig. S2A–F), suggesting that CDN is a potent and broad inhibitor ...
in jukeboxes near the MSU campus. FSRS-3301 - Kenneth G. Bloomquist, Director - Michigan State University Spartan Marching Band [1963?] Traditional Spartan March To Stadium/State Fanfare-"Eat 'Em UP"-MSU Pre- Game Fight//Spartan Fanfare-MSU Fight Song-MSU Shadows Fontana Fontana's Little...
探讨白藜芦醇对单钠尿酸盐(monosodium urate, MSU)晶体诱导小鼠RAW264.7巨噬细胞的炎症因子,氧化应激指标及核因子E2相关因子2 (nuclear factor erythroid-2-related f... 冯佳、黄侠、李赫宇、鞠单、杨年安、田瑞、夏燕、袁林 - 《药学学报》...
WAS inhibited the production of IL-1β, but not IL-6, in response to adenosine triphosphate (ATP) and monosodium uric acid (MSU) crystals in LPS-primed BMDMs. Cleavage of caspase-1 and IL-1β was also reduced by WAS. We finally evaluated the in vivo anti-inflammatory effects of WAS ...
我用1ug/ML 的LPS (sigma)刺激THP-1细胞,24小时后取上清用BD公司CBA检测TH1/TH2/细胞因子谱,居然都是接近零。 重复一次 LPS浓度( 0,10ng,100ng,1000ng,10ug,20ug,50ug) / ml,孵育细胞24小时,取上清上机,结果仍然没有。 这是我准备做炎症细胞模型的,现在没法进行,请好心人指点。
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