虽然 GBP1、2、3 和 4 都存在于细菌表面,但尚不清楚每种 GBP 如何促进 caspase-4 的激活。 Shigella flexneri 是研究 caspase-4 炎性体的 GBP 调节的有用模型病原体,因为它编码调节该过程的特定效应子; OspC3 阻断 caspase-4 激活,IpaH9.8 通过降解 GBP1、2 和 4 来减少 GBP 细菌靶向。 S. flexneri...
As the molar ratio of caspase-4 to LPS increases, the size of the caspase-4/LPS complex decreases. Our results present a new function of caspase-4 and set the stage for structural and biochemical studies, and drug discovery targeting LPS/caspase-4 interactions by establishing a facile ...
The human non-canonical inflammasome controls caspase-4 activation and gasdermin-D-dependent pyroptosis in response to cytosolic bacterial lipopolysaccharide (LPS). Since LPS binds and oligomerizes caspase-4, the pathway is thought to proceed without ded
LPS转染进入巨噬细胞，可以结合caspase 1, 引起细胞焦亡。
为了进一步阐明PEBP4的作用和机制,我们利用PDTC和TAK-242进行研究,结果表明,两者都能部分逆转PEBP4 CKO对ALI的影响,包括肝脏病理改变(图4A)、ALT/AST、MPO活性(图4B, C)、炎症因子表达水平(图4D, E)、肝细胞凋亡(图4F)、以及caspase -3、-8和-9的表达和活性(图4G, H)。为了进一步证明其对TLR4/NF-κB信号...
Juglanin significantly reduced cellular oxidative stress by downregulating NOX4 expression production and rescuing the decreased activity of total SOD induced by LPS. Juglanin inhibited the activation of the TxNIP/NLRP3/ASC/caspase-1 axis, and decreased production of IL-1尾 and IL-18. Moreover, ...
Meanwhile, differentially expressed genes like Gfap, Ccl5, Caspase4 and Caspase8 were still increased after fluoxetine treated (Fig.3F, Fig.S1H). Altogether, our results indicated that fluoxetine may improve the depressive-like behaviors induced by LPS via regulating the expression of Nr4a2 and ...
The canonical activation of the inflammasomes, such as NLRP3 inflammasome, is critical to promote the caspase-1-dependent maturation of pro-inflammatory cytokines, IL-1β and IL-18 [32]. Moreover, LPS stimulated the mouse peritoneal macrophages to induce the production of pro-IL-1β and pro-...
Cav‐1 deletion significantly reduced LPS/GalN‐induced caspase‐3, caspase‐8 and caspase‐9 activation and pro‐inflammatory cytokine and chemokine expression. Additionally, Cav‐1−/− mice showed suppressed expression of Toll‐like receptor 4 (TLR4) and CD14 in Kupffer cells and reduced ...
| 细胞焦亡:一种新兴的抗肿瘤免疫治疗方法 近年来,科学家们发现了一种被称为细胞焦亡的细胞死亡机制,该机制被证实可以诱发强效且有效的抗肿瘤免疫反应。细胞焦亡是由gasdermin家族打孔蛋白执行的促炎性细胞死亡。gasdermin D(GSDMD)被炎症小体激活的caspase-1和LPS激活的caspase-11/4/5切割,释放出其成孔结构域。利...