NLRP3 plays a pivotal role in the activation and assembly of NLRP3 inflammasome [46]. It can respond to pathogens (PAMPs) and endogenous activators (DAMPs), such as microbes, extracellular ATP, viral RNA, mitochondrial dysfunction, endoplasmic reticulum (ER) stress, and lysosomal rupture [47,...
and at an FDR > 0.2 threshold in the opposite sex (Table1and Supplementary TableS4). Of the 237 LPS-responsive genes in both males and females, only one gene responded in opposite directions: ERCC excision repair 6 like (ERCC6L), a DNA helicase for spindle assembly, which increased ...
can activate potent inflammatory responses and has been associated with many inflammatory and autoimmune diseases, including diabetes, atherosclerosis, asthma, systemic lupus erythematosus and rheumatoid arthritis [22,23,45]. NLRP3 plays a pivotal role in the activation and assembly of NLRP3 inflammasome...