LPS/Toll信号通路c-fos基因AP-1NF-κBIL-12p40基因烫伤能够引起机体免疫系统功能的抑制,其机制目前还不很清楚,巨噬细胞在机体防御系统的调节中居重要地位,因此研究烫伤对巨噬细胞的效应就显得非常必要,转录因子AP-1和NF-κ是Toll样受体介导的信号通路中的重要成员,对于多种参与免疫反应的基因尤其是细胞因子基因的...
目的建立小鼠内毒素(即脂多糖,LPS)急性肺损伤(ALI)模型,动态观察槐定碱对小鼠内毒素性肺损伤模型的治疗作用,研究槐定碱对LPS信号转导途径中的识别受体-LBP,CD14,TLR4,胞内p38MAPK信号分子,核转录因子AP-1及主要炎症介质TNF-α,NO四个层次的影响,以探讨其抗内毒素的药理机制. 方法BALB/c小鼠随机分为6组,即正常对...
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MAPK is an important signaling pathway for regulation of the immune response and inflammatory factor expression and has an important role in regulating NF-κB activation, and phosphorylation of MAPK is closely related to modulation of AP-1 activation. We therefore investigated the effect by pretreatmen...
In summary, our results demonstrated that OEA exerts anti-inflammatory effects by enhancing PPARα signaling, inhibiting the TLR4-mediated NF-κB signaling pathway, and interfering with the ERK1/2-dependent signaling cascade (TLR4/ERK1/2/AP-1/STAT3), which suggests that OEA may be a therapeutic...
新品展示 NICHIBAN双面胶NW-5 NW- 中京化成C-Y TYPE气化性... LPS 2重型润滑油 强力油... UltraTape胶带 1310不锈... D-1 MIST山一化学气化性 SUPPLE MIST山一化学(YA... 山一化学(YAMAICHI)高温... PART II气化性防锈剂山...
FSB also reduced the LPS-induced inductions of TNF-alpha, IL-6 and IL-1 beta at protein and mRNA levels. Studies of the molecular mechanisms involved in the anti-inflammatory effects of FSB showed that it inhibited the transcriptional activities of NF-kappa B and AP-1, and the nuclear ...
型号 LPS331APTR 型号 LPS331APTR 品牌 ST/意法 批号 21+ 封装 LGA16 QQ 2192603380 价格说明 价格:商品在爱采购的展示标价,具体的成交价格可能因商品参加活动等情况发生变化,也可能随着购买数量不同或所选规格不同而发生变化,如用户与商家线下达成协议,以线下协议的结算价格为准,如用户在爱采购上完成线...
These findings show that HSFE exerts anti-inflammatory effects by suppressing the activation of MAPK, AP-1, JAK2/STAT, and NF-κB signaling pathways in LPS-stimulated macrophages. In addition, the anti-inflammatory efficacy of HSFE appears to be closely related to the action of the three main...
Transcription Factor AP-1NF-kappa BInflammation MediatorsNeutrophil InfiltrationThe nature of the chronic inflammatory component that drives the development of non-alcoholic steatohepatitis (NASH) is unclear and possible inflammatory triggers have not been investigated systematically. We examined the effect ...