Motor neuron diseaseNSC-34 cell lineNeurite outgrowthMotor neuron diseases (MND) including amyotrophic lateral sclerosis and Parkinson disease are commonly neurodegenerative, causing a gradual loss of nerve cells and affecting the mechanisms underlying changes in calcium (Ca 2+ )-regulated dendritic ...
L. et al. Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 18, 459–480 (2019). Article Google Scholar Eggers, R. et al. Timed GDNF gene therapy using an immune-evasive gene ...
Patients with amyotrophic lateral sclerosis where pyramidal tract involvement is present show greatly raised CSF NfL levels, while those with only peripheral motor neuron disease (progressive muscular atrophy) show smaller elevations [2, 3]. Multiple sclerosis cases in the chronic progressive phase of ...
Therefore, future studies investigating LI-rTMS on functional outcomes in pre-clinical injury and disease models would reveal which populations and disorders might benefit from LI-rTMS. Materials and Methods Animals 10 week old male C57Bl/6 J mice (Mus Musculus) (UTAS colony originally derived ...
Since clinical features of chronic muscle pain originating from the low back and limbs are different (higher prevalence and broader/duller sensation of low back muscle pain than limb muscle pain), spinal and/or supraspinal projection of nociceptive infor
Introduction Mild cognitive impairment is an early condition in patients who are often subsequently diagnosed as having Alzheimer’s disease (AD). Similarly, experimental models (e.g., the 5xFAD mouse) that mimic hallmark AD neuropathology exhibit cognitive deficits [1,2]. Since its development in...
1C). Reflecting both disease severity and the above mentioned fatal outcome, we noticed that high-dose PLX5622 pretreated animals developed an increased number of intracerebral hemorrhages following the induction of polymicrobial sepsis (Fig. 1D). PLX5622 depletes also peripheral immune cells, in ...
Morris G, Berk M, Carvalho A, Caso JR, Sanz Y, Walder K, Maes M (2017) The role of the Microbial metabolites Including Tryptophan catabolites and short chain fatty acids in the pathophysiology of Immune-Inflammatory and Neuroimmune Disease. Mol Neurobiol 54:4432–4451. https://doi.org/10.1...
Examination of the interaction of parameters for low-intensity focused ultrasound of the human motor cortex. Brain Stimul. https://doi.org/10.1016/j.brs.2024.11.005 (2024). Murphy, K. R. et al. Optimized ultrasound neuromodulation for non-invasive control of behavior and physiology. Neuron 112...
Alcohol use disorder has been associated with the development of neurodegenerative diseases, including Alzheimer’s disease (AD). However, recent studies demonstrate that moderate alcohol consumption may be protective against dementia and cognitive decli