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262 adults with type 2 diabetes (average age 54) were enrolled in the intervention group, called CCI (digitally-monitored continuous care intervention via a web-based app). 87 were assigned to “usual care.” For all participants at baseline,body mass indexaveraged 37-40, HgbA1c averaged 7.6...
The aim of the present study was to investigate the effect of low-normal and high-normal levels of IGF-1 in growth hormone (GH) deficient adults on cognition and wellbeing during GH treatment. A randomized, open-label, clinical trial including 32 subjects receiving GH therapy for at least ...
No differences in adiponectin levels were found between birth weight groups. Conclusions Middle-aged adults born with a low weight present a higher prevalence of diabetes and obesity and also higher leptin levels and leptin to fat mass ratio than adults born with a normal weight. The higher ...
In adults, gliomas are the most common type of malignant brain tumors, making up 80% of all the malignant brain tumors3,4, with a universally fatal outcome due to common recurrence and progression. Current routine glioma treatment includes surgery, radiation, chemotherapy, immunotherapy5, targeted...
Association between sarcopenic obesity and higher risk of type 2 diabetes in adults: A systematic review and meta-analysis. World J Diabetes. 2019;10(5):311–23. Article PubMed PubMed Central Google Scholar Givi M, Sadeghi M, Garakyaraghi M, Eshghinezhad A, Moeini M, Ghasempour Z. ...
inadultsandsuggestthaturicacidmightaffecthepaticIGF-1synthesis. ª2014ElsevierB.V.Allrightsreserved. Acronyms:ALT,alanineaminotransferase;ADA,AmericanDiabetesAssociation;AST,aspartateaminotransferase;BMI,bodymassindex; DMEM,Dulbecco’sModifiedEagle’sMedium;eGFR,estimatedGFR;FPG,fastingplasmaglucose;GGT,gamma...
Free insulin-like growth factor I serum levels in 1430 healthy children and adults, and its diagnostic value in patients suspected of growth hormone defici... Serum levels of total insulin-like growth factor I (IGF-I) and IGF-binding protein-3 (IGFBP-3) reflect endogenous GH secretion in ...
For instance, mutations in several conserved genes are known to extend lifespan in the nematode C. elegans, including the insulin/IGF-1signalling receptor mutant daf-23, the feeding deficient mutant eat-24, the ubiquinone synthesis mutant clk-1 that impairs mitochondrial respiration5, the Notch ...
Dietary proteinis the major dietary regulator of a growth hormone known as IGF-1, which has been associated with aging and diseases in mice and several diseases in older adults. Upcoming studies by USC Professor Valter Longo, the study's corresponding author, will attempt to determine whether hu...