Twelve women with low-grade dysplasia, confirmed by colposcopic exam, were given 150聽mg of intravaginal micronized DHEA daily for up to 6聽months. Follow-up evaluations of the cervix were done at 3 and 6 months of use. DHEA, DHEA-S, androstenedione and testosterone levels were also ...
However, one patient had invasion >10.0 mm as well as positive cone margins for high-grade dysplasia and the other two patients had an inadvertent simple hysterectomy. The inclusion criteria for the trial were changed based on these findings as described above. Of note, none of the recurrences...
Peripheral blood lymphocytes from low-grade squamous intraepithelial lesions patients recognize vaccine antigens in the presence of activated dendritic cells, and produced high levels of CD8 + IFNy"1" T cells and low levels of IL-2 when induced to proliferate [J]. Infectious Agents and Cancer,...
16, 17, 18 Infection with high-risk HPV has been associated with malignant transformation, and causally related to cervical cancer19, 20 and a subset of squamous cell carcinomas in the head and neck and anogenital region different from the cervix.21, 22, 23 Verrucous carcinoma has been ...
et al. HPV vaccination leads to decrease of anogenital warts and precancerous lesions of the cervix uteri in young women with low vaccination rates: a retrospective cohort analysis. BMC Cancer 22, 1293 (2022). https://doi.org/10.1186/s12885-022-10214-1 Download citation Received10 November ...
grade lesions and normal cervix. Current worldwide emphasis on screening populations for HPV is well-placed since it identifies those at higher than normal risk of developing cervical cancer. However, HPV testing does not identify those with high-grade intraepithelial lesions (HSIL) or carcinoma who...
Indeed, overexpression of p16INK4a is known to be observed in cancers of the uterine cervix (Schorge et al, 2004), which is almost always associated with HPV infection. In order to shed light on the aetiological involvement of HPV, we conducted IHC of p53 and p16INK4a. However, we ...
cancer if left untreated. However, the diagnostic categories currently available have only modest predictive value, and that value decreases as the lesions become less severe. The likelihood of progression to cancer is higher and the time to progression is shorter as the grade of dysplasia increases...
Conization is recommended for the treat- ment of dysplasia when out-patient treatment is not 329 GYNECOLOGY FOR LESS-RESOURCED LOCATIONS feasible or not accessible, and to rule out invasive cervical cancer. It is a rather extensive operation, involving removal of a large area of the cervix with...
[2.0 mg/dL]); prior history of malignancy other than MDS (except basal cell or squamous cell carcinoma or carcinoma in situ of the cervix or breast) unless free of disease for at least 3 years; clinically significant coexisting medical conditions; and prior grade 3 or 4 allergic reaction ...