The estimated mutation rate is 17-fold lower than in humans and an order of magnitude lower than the slowest evolving mammal recorded to date (Supplementary Table1). However, it should be noted that this estimate reflects the mutation rate in the callable fraction of the genome, which does no...
The highly polymorphic human leukocyte antigen (HLA) plays a crucial role in adaptive immunity and is associated with various complex diseases. Accurate analysis of HLA genes using ancient DNA (aDNA) data is crucial for understanding their role in human
Each column of subplots corresponds to the simulated WGA noise fraction. Error bars correspond to upper and lower quartiles. Full size image Even in low-coverage scenarios the methods are often able to correctly recall true motifs. In the case of E.coli and G. metallireducens, this stays ...
When set, the device clears the HIGH_Alert status flag if the conversion result goes below the value in the low limit register. Thus, the difference between the high and low limits effectively acts like a hysteresis. In this mode, the LOW_Alert status flag is disabled and always reads 0....
The SARS-CoV-2-specific CD8+T cell response is a key mechanism for the prevention of SARS-CoV-2 infection29,30. Patients with virus-specific CD8+T cells in the acute phase have a better prognosis after infection, implying that CD8+T cells contribute to the control of SARS-CoV-2 infection...
The determination of the thermodynamic quantities of subcooled water on the basis of this equation of state requires the iterative determination of the fraction of low-density water in the two-state mixture of low-density and high-density subcooled water from a transcendental equation. For ...
Unaligned reads were then mapped to the mouse genome (mm9) using TopHat (v1.4.1; parameters: min-isoform-fraction 0, max-multi-hits 1, no-closure-search, no-coverage-search, bowtie-n and initial-read-mismatches 3). We calculated Reads Per Kilobase per Megabase (RPKM) of the library ...