We designed a new regimen to evaluate the efficacy and feasibility of weekly low dose CPT-11 combined with 5-FU/l-LV therapy based on an RPMI regimen against advanced and recurrent colorectal cancer. Twenty patients were enrolled in this study. Weekly administration (CPT-11; 60 mg/m(2) ...
While positive or negative obesity outcomes are often measured, the feeding behaviors of animals in these experiments that could account variabilities in the result, as with the dose and composition of the plant materials themselves, need to be looked at. The other source of variability comes with...
Bourgeois H, Vermorken J, Dark G, et al. Evaluation of oral versus intravenous dose of vinorelbine to achieve equivalent blood exposures in patients with solid tumours. Cancer Chemother Pharmacol. 2007;60(3):407–13. PubMedCASGoogle Scholar Eckardt JR, von Pawel J, Pujol J-L, et al. Pha...
OVARIAN-CANCERIN-VITROAUTOPHAGYINHIBITIONIRINOTECANWe have previously reported that the combination of low-dose (5.9 mg/kg/dose) irinotecan (CPT-11) and simultaneous low-dose (5 mg/kg/dose) celecoxib, a cyclooxygenase-2 inhibitor, administered for 20 consecutive days, had synergistic antitumor ...
The current case suggests that weekly low-dose CPT-11/Isovorin/5-FU may have a potent therapeutic effect against recurrent rectal cancer.癌と化学療法Shinohara HHara HToyoda MHiramatsu MSako STanigawa NDept. of General and Gastroenterological Surgery Osaka Medical College....
PROLONGED LOW-DOSE GLUCOCORTICOID IMPACT ON VENTILATORY AND LOWER EXTREMITY MUSCLES IN PATIENTS WITH ADVANCED LUNG DISEASE.An abstract is unavailable. This article is available as a PDF only.doi:10.1097/01823246-200112040-00026ParkhillK AOvid Technologies (Wolters Kluwer Health)...
In the present study we examined the effect of CPT-11 in rat pheochromocytoma PC12 cells. When PC12 cells were treated with CPT-11, two distinct reactions were encountered. A high dose of CPT-11 induced apoptotic cell death mediated by caspase cascade, whereas a low dose of CPT-11 ...
EFFECTS OF AMBULATION AND NON-DEPENDENT TRANSFERS ON VITAL SIGNS IN PATIENTS RECEIVING LOW DOSE LEVOPHED IN AN ACUTE CARE SETTING: A RETROSPECTIVE PILOT STUDY.An abstract is unavailable. This article is available as a PDF only.doi:10.1097/01823246-201223040-00039Fick Ann...
A 46-year-old Japanese female with advanced gastric cancer with positive peritoneal cytology and who was refractory to methotrexate plus 5-FU sequential chemotherapy received low-dose, fractional irinotecan hydrochloride (CPT-11) in combination with cisplatin. This regimen could be repeated biweekly on...
Methods CPT-11 (27mg/m 2 ) and CDDP (6mg/m 2 ) were administered on days1, 8 and 15 every 4weeks to 20 patients with recurrent or metastatic colorectal cancer. When toxicities were noted, administrations were delayed or the dose was reduced. Results No severe toxicity (i.e. grade3 ...