We designed a new regimen to evaluate the efficacy and feasibility of weekly low dose CPT-11 combined with 5-FU/l-LV therapy based on an RPMI regimen against advanced and recurrent colorectal cancer. Twenty patients were enrolled in this study. Weekly administration (CPT-11; 60 mg/m(2) ...
The current case suggests that weekly low-dose CPT-11/Isovorin/5-FU may have a potent therapeutic effect against recurrent rectal cancer.癌と化学療法Shinohara HHara HToyoda MHiramatsu MSako STanigawa NDept. of General and Gastroenterological Surgery Osaka Medical College....
RISK OF ECTOPIC PREGNANCY WITH LOW-DOSE PROGESTOGEN OCs IS HIGHInpharma Weekly -doi:10.1007/BF03289196Springer International PublishingInpharma
dose-response effects of amphetamine (0, 0.1, 0.3, or 1.0 mg/kg) and haloperidol (0, 3.2, 10, or 32 μg/kg) on 5C-CPT performance in Long Evans rats, and then tested an amphetamine (0.3 mg/kg) × haloperidol (10 μg/kg) interaction; the low dose was chosen because higher dos...
EBSCO_AspBmj British Medical Journal
Kurzrock R, Talpaz M, Gomez JA, et al: Differential dose-related haematological effects of GM-CSF in pancytopenia: evidence support- ing the advantage of low- over high-dose administration in selected patients. Br J Haematol 78:352, 1991....
A high dose of CPT-11 induced apoptotic cell death mediated by caspase cascade, whereas a low dose of CPT-11 induced irreversible cell morphological changes. The cell shape of the transformed PC12 cells was similar to fibroblasts, and these were termed FLTP12 (fibroblast-like transformed PC12)...
PROLONGED LOW-DOSE GLUCOCORTICOID IMPACT ON VENTILATORY AND LOWER EXTREMITY MUSCLES IN PATIENTS WITH ADVANCED LUNG DISEASE.An abstract is unavailable. This article is available as a PDF only.doi:10.1097/01823246-200112040-00026ParkhillK AOvid Technologies (Wolters Kluwer Health)...
A 46-year-old Japanese female with advanced gastric cancer with positive peritoneal cytology and who was refractory to methotrexate plus 5-FU sequential chemotherapy received low-dose, fractional irinotecan hydrochloride (CPT-11) in combination with cisplatin. This regimen could be repeated biweekly on...
We report a case of recurrent colon cancer resistant to 5-FU, whose QOL and PS has been well maintained with low-dose CPT-11/CDDP administered on an outpatient basis for more than 28 months. A 42-year-old male had lymph node recurrence 27 months after curative resection of colon cancer....