Two differentially expressed proteins, alpha-1-acid glycoprotein 1 (A1AG1) and A1AT, exhibited 2-fold differences, and their HNE modifications were identified by depleted-albumin and immunoglobulin G (IgG) serum protein, in-solution digestion, in-gel digestion, and nano-LC-MS/MS from pSS ...
Further, we used our previously described algorithm BONITA to reveal a critical role for Lymphocyte Specific Protein 1 (LSP1) in cytoskeletal rearrangement. LSP1 is known to modulate neutrophil migration. Validating these modeling results, we show experimentally that LSP1 levels in B cells increase ...
Hgb is made up of four protein molecules (globulin chains) that are connected. The normal adult hemoglobin molecule contains two alpha-globulin chains and two beta-globulin chains. In fetuses and infants, beta chains are not common and the hemoglobin molecule is made up of two alpha chains and...
Thalassemia is a genetic disease that is caused by one or more genes that control the production of either the alpha or beta protein that make up the structure of hemoglobin. A person has alpha or beta thalassemia; these two types have many subtypes but are usually grouped into one of two ...
Recent research suggests that protein deficiency symptoms are influenced by the intestinal microbiota. We investigated the influence of low protein diet on composition of the intestinal microbiota through animal experiments. Specific pathogen-free (SPF)
We further show that streptonigrin treated cells exhibit compacted DNA foci in the nucleus that co-localize with Heterochromatin Protein 1 alpha (HP1α), and exhibit an increase in total levels of the heterochromatin mark, H3K9me3. Interestingly, we found that streptonigrin promotes heterochromatin ...
Our results show that low levels of HIF-1α mRNA or EGFR mRNA are negative independent prognostic markers for STS patients, especially after combination of both parameters. The protein levels showed a different effect on the prognosis. In addition, our analysis suggests a possible association ...
Sometimes, a very low HDL count is caused by genes that run in families. These include conditions like Tangier’s disease, caused by mutations in the ABCA1 gene, and another calledfamilial hypoalphalipoproteinemia, caused by mutations of the APOA1, ABCA1, or LCAT genes.3 ...
The expression of tumor necrosis factor-alpha, its receptors and steroidogenic acute regulatory protein during corpus luteum regression p pBackground/p pCorpus luteum (CL) regression is known to occur as two parts; functional regression when steroidogenesis declines and structural regressio... M Abdo...
albumin, beta-2-microglobulin (B2M), cystatin C, epithelial growth factor (EGF), neutrophil gelatinase-associated lipocalin (NGAL), osteopontin (OPN), and uromodulin (UMOD), kidney injury molecule-1 (KIM-1), clusterin, and alpha-glutathione-S-transferase (αGST). Our research questions include...