The aim of this study was to examine oxidative stress and low level of alpha-1-antitrypsin (A1AT) in primary Sjgren's syndrome (pSS), and evaluate the associated autoreactivity against unmodified and their 4-hydroxy-2-nonenal (HNE)-modified peptides with pSS. Two differentially expressed ...
Fig. 1 A Analysis of serum Glycoproteins. Plasma samples from normal subject (N), and the patient (P) were submitted to SDS PAGE followed by Western-blot analysis of 4 seric glycoproteins: Haptoglobin (HPT), Orosomucoid (ORO), alpha-antitrypsin (AAT) and transferrin (TRF). The molecular we...
Alpha-1-antitrypsin, S100A9 and gastric intrinsic factor have been proposed as biomarkers in gastric fluid (Hsu et al, 2007; Wu et al, 2012), whereas alpha-defensins (Kim et al, 2010) and Cathepsin B (Ebert et al, 2005a) have been identified from tissue analysis. Other recently ...
The amounts of alpha 1 antitrypsin protein are reduced in the vascular wall of the acutely dissected human ascending aorta. Eur. J. Cardiothorac. Surg. 2010, 37, 684–690. [Google Scholar] [CrossRef] [Green Version] Allaire, E.; Schneider, F.; Saucy, F.; Dai, J.; Cochennec, F....
ST3 beta-galactoside alpha-2,3-sialyltransferase 4 (ST3GAL4, Chr 11) plays a key role in the synthesis of E-selectin ligands, influencing enzyme liver concentrations [121]. The ABO blood group (ABO, Chr 9) gene is also associated with serum soluble E-selectin levels [122], and there ...
With serum, the number resolved is much lower because of the presence of large amounts of albumin, transferrin, haptoglobin, α2-HS glycoprotein, α1-antitrypsin, Gc globulin, α1 acid glycoprotein (orosomucoid), and Ig chains. For urine, similar problems exist due to the presence of IgG, ...
We also observed fragments of much larger proteins known to play a physiological role including the C terminus of alpha1-antitrypsin (SERPINA1), or SPAAT, which regulates neutrophil extracellular trap (NET) formation (31). To fully characterize the components of this fraction, we performed ...
Alpha-1-antitrypsin A1AT_HUMAN 5.37 46,878 1031 60 Ig gamma-3 chain C region IGHG3_HUMAN 8.23 42,287 249 34 Alpha-2-HS-glycoprotein FETUA_HUMAN 5.43 40,098 209 13 Kininogen-1 KNG1_HUMAN 6.34 72,996 143 11 Beta-2-glycoprotein 1 APOH_HUMAN 8.34 39,584 177 29 Ig gamma-4 chain C...
and antitrypsin, whereas Human 14 removes the high and intermediate abundant proteins by binding the six proteins indicated above plus alpha-2-macroglobulin, alpha-1-acid glycoprotein, IgM, apolipoprotein AI, apolipoprotein AII, complement C3 and transthyretin. These immunoaffinity steps provide the inter...
These results suggest that NMDA receptor stimulation during CGN development differentially regulates the two AAT isoenzymes involved in the maturation of CGN and that the regulation of both AAT and PAG occurs also at the mRNA expression level, suggesting the involvement of a mechanism of gene ...