Discusses that the elderly people with chronic hypertension show abnormal loss of brain cells. Study on the correlation between the number of years a person has high blood pressure and the amount of brain tissue los...
Adverse experiences in early life can shape neuronal structures and synaptic function in multiple brain regions, leading to deficits of distinct cognitive functions later in life. Focusing on the pyramidal cells of the prelimbic cortex (PrL), a main subregion of the medial prefrontal cortex, the ...
In TLE, many seizures, known as focal seizures, originate in one part of the brain and are evident on electroencephalography (EEG) scans that show the brain’s electrical activity. These seizures can result in symptoms such as twitching or a strange taste or smell, and many people with TLE...
the brain is composed of other types of cells that also are very important," said first author Courtney Sobieski. "Astrocytes are support cells that appear to play a key role in the development of healthy neurons. The neurons have trouble communicating without the support of astrocytes." ...
Batten disease, one of the most devastating types of neurodegenerative lysosomal storage disorders, is caused by mutations in CLN3. Here, we show that CLN3 is a vesicular trafficking hub connecting the Golgi and lysosome compartments. Proteomic analysis
Handbook of Stress and the Brain Randall R.Sakai,Kellie L.K.Tamashiro, inTechniques in the Behavioral and Neural Sciences, 2005 Physiological changes Body weight lossis one of the most dramatic and consistent changes resulting from chronic social stress (Barnett, 1958;Barnett et al., 1960;Dijkst...
S3l). Both OXR1 deficient patients [4] and OXR1 knockout mouse models [5, 12] showed cerebella related symptoms after birth. In lack of the access to viable human brain tissues, human brain organoids are the only models enabling advanced studies of brain development and patho-mechanisms. ...
However, in Brca1−/−;Trp53bp1−/− mice that were viable with no obvious symptoms at 5 months, early stage thymic lymphomas containing CD4 and CD8 double positive lymphocytes were frequently observed (Figs. S1 and S2). Histological examinations revealed that cell organization of the ...
There exists an intricate relationship between hypercholesterolemia (elevated plasma cholesterol) and brain functions. The present study aims to understand the impact of hypercholesterolemia on pathological consequences in mouse brain. A chronic mouse mo
These signals then travel from the eyes through the optic nerves to the brain. In the brain, the occipital lobes process the visual information to make sense of it. Problems at any point along this visual pathway can cause vision loss. Signs and Symptoms Sudden vision loss is vision loss ...