Contrary to expected outcomes associated with increasing endocannabinoid tone, loss of ABHD6 in nucleus accumbens, but not ventral tegmental area, neurons completely prevents diet-induced obesity, reduces food- and drug-seeking and enhances physical activity without affecting anxiodepressive behaviour. ...
Members of the KMT2C/D–KDM6A complex are recurrently mutated in urothelial carcinoma and in histologically normal urothelium. Here, using genetically engineered mouse models, we demonstrate that Kmt2c/d knockout in the urothelium led to impaired differe
For the purposes of our analyses here, we only included studies of terrestrial insects because many of our datasets on aquatic insects within the InsectChange database18did not have a consistent taxonomic resolution over time to calculate reliable biodiversity metrics, and larger, more comprehensive s...
Transposable elements (TEs) through evolutionary exaptation have become an integral part of the human genome, offering ample regulatory sequences and shaping chromatin 3D architecture. While the functional impacts of TE-derived sequences on early embryog
The communication session does not end until the health care provider indicates that it has no further questions to ask the patient. Thus, the health care provider may adapt its questions in real-time, based upon the answers received from the patient 1105....
This method selects the average value of the voltage vector sum at both ends of the cable as the measurement voltage, the load current does not affect the measurement of tanδ, harmonics and frequency fluctuations have little effect on the method, and the method is not limited to the ...
Only two junction-spanning piRNAs have a perfect match in the micronuclear genome of just 27 nt, which is not very different from 0.14 expected by chance, based on assumptions of sequence uniformity. This study therefore revealed no evidence of piRNA-specific loci in the micronuclear genome. ...
However, in cKOs, we did not see a reduction until after P25. Rather, tdTomato+ numbers remained unchanged from P7 through P35, with this trend still present by P50. We first saw a significant difference in numbers between cKOs and WTs or cHets at age P25 (Figure 2D,E; Figure S1)...
Based on the magnetic field distribution caused by permanent magnet and armature reactions, the stator core loss can be calculated with the core loss analytical model, corresponding to the rotational magnetic field. In this study, the method has been applied to analyze core loss in an interior ...
This resulted in an empirical FDR estimated at 15% (i.e. precision of 85%), based on the knownTP53mutations. Importantly this 15% is a conservative upper-bound estimate of FDR, since it is based on the assumption that there do not exist any unknownTP53phenocopying events: it classifies ...