In the cochlea, glutamate receptors mediate fast synaptic transmission at the IHC afferent synapse and glutamate excitotoxicity is central to the neural damage during acoustic trauma35,36. Clinically, the audiogenic seizure pathology in BLSW mice is a form of reflex epilepsy, in which external ...
ABR wave I amplitude and seizure resistance in BLSW mice may be indicative of a neuropathy at the IHC spiral ganglion neuron synapse. In the cochlea, glutamate receptors mediate fast synaptic transmission at the IHC afferent synapse and glutamate excitotoxicity is central to the neural damage ...