HIGH-DOSE losartan taken by patients with heart failure is not associated with an increased risk of death compared with candesartan, the findings of a study published online in JAMA (11 April 2012) suggest.Researchers analysed Danish registry data (see Panel). Low-dose losartan (12.5mg) was ...
Marvin A.Konstam,Richard D.Patten, inHeart Failure: A Companion to Braunwald's Heart Disease (Second Edition), 2011 Second Evaluation of Losartan in the Elderly (ELITE-II) The ELITE-II trial70tested the hypothesis that theARBlosartan(target dose, 50 mg/day) would reduce mortality in relation...
Usual Pediatric Dose for Hypertension: 6 Years or Older: Initial dose: 0.7 mg/kg orally once a day (up to 50 mg total) Comments: -May be given as a tablet or suspension. -Doses above 1.4 mg/kg (or 100 mg) daily have not been studied in pediatric patients. ...
the recommended blood pressure target is less than 130/80 mm Hg. The ACC and AHA recommend a thorough follow-up evaluation for cardiovascular patients, which includes assessing blood pressure control, orthostatic hypotension, medication adverse effects, medication ...
SummaryBackground Angiotensin-receptor blockers (ARBs) are effective treatments for patients with heart failure, but the relation between dose and clinical... Marvin,A,Konstam,... - 《Lancet》 被引量: 494发表: 2009年 Incident hyperkalemia may be an independent therapeutic target in low ejection...
In stage 1 hypertension, experts state that it is reasonable to initiate drug therapy using the stepped-care approach in which one drug is initiated and titrated and other drugs are added sequentially to achieve the target BP. Initiation of antihypertensive therapy with 2 first-line agents from ...
It has also been tried in heart failure (below) and in myocardial infarc- tion (p.1175). Losartan is given orally as the potassium salt. The maximum hypotensive effect is achieved in about 3 to 6 weeks after starting treatment. In hypertension the usual dose of losartan potassium is 50 ...
What should I do if I miss a dose of losartan/hydrochlorothiazide? If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and only take the next dose. Do not take double or extra doses....
Losartan increases AMPK phosphorylation in a time- and dose-dependent manner in VSMCs. It also increases ACC phosphorylation, a major downstream target protein in the AMPK signaling cascade, and LKB1 phosphorylation, which is an upstream kinase of AMPK. Losartan increases p53 and p21 expression in...
intradialytic hypotension is associated with mortality29,30, thereby raising questions regarding the recommended post-dialysis blood-pressure target range. Similarly, studies indicate a U-shaped or reverse J-shaped relationship between systolic blood pressure and mortality among ESRD patients31,32. Hence,...