unmetabolized losartan as an inhibitor of AT and is a non-competitive inhibitor. Losartan's prevention of angiotensin II binding causes vascular smooth muscle relaxation, lowering blood pressure.Angiotensin II would otherwise bind to the AT receptor and induce vasoconstriction, raising blood pressure. ...
Baseline pre-dialysis blood pressure among standard-arm patients was 167.5 mmHg (SD ± 18.2), which at the end of the 12-month follow-up was reduced to 162.4 mmHg (SD ± 10.2), giving a difference of 5.1 mmHg. This drop in pre-dialysis systolic blood pressure was sta...