HCTZ dissolved in 0.5% carboxymethylcellulose was administered by gavage daily at a dose of 80 mg kgÀ1 dayÀ1 in the FFR+HCTZ and FFR+HCTZ+LOS groups. Because one aim of the study was to examine the effect of losartan on IS exacerbated by HCTZ, we selected the highest dosage of ...
Losartan potassium was not carcinogenic when administered at maximally tolerated dosages to rats and mice for 105 and 92 weeks, respectively. Female rats given thehighest dose (270 mg/kg/day) had a slightly higher incidence of pancreatic acinar adenoma. The maximally tolerated dosages (270 mg/kg...
If 8,000 people took the highest dose from recalled batches every day for four years, there would likely be one additional case of cancer over the life of those people, the agency estimates. Torrent said it's only recalling lots containing NMBA above what the FDA considers acceptable for da...
We previously reported echocardiographic evidence of pulmonary hypertension in over 50% of patients attending a hospital clinic for COPD [5], with the highest prevalence in those with severe disease. Alveolar hypoxia undoubtedly contributes to pulmonary hypertension in COPD and there is a correlation, ...