Comparison of Rapidly Acting Intramuscular Olanzapine, Lorazepam, and Placebo: A Double-blind, Randomized Study in Acutely Agitated Patients with Dementia This double-blind study investigated the efficacy and safety of rapid-acting intramuscular olanzapine in treating agitation associated with Alzheimer's di...
Suddenly stopping therapy after a few months of daily therapy may be associated with a feeling of loss of self-worth, agitation, and insomnia. If lorazepam is taken continuously for longer than a few months, stopping therapy suddenly may produce seizures, tremors, muscle cramping, vomiting, and...
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Conclusions: Despite being short term and small, the present study suggests that divalproex sodium may be more effective and safer than lorazepam for the treatment of agitation or anxiety related to dementia in LTC facility residents. Larger, longer-term controlled studies are recommended to further ...
Comparison of Rapidly Acting Intramuscular Olanzapine, Lorazepam, and Placebo: A Double-blind, Randomized Study in Acutely Agitated Patients with Dementia This double-blind study investigated the efficacy and safety of rapid-acting intramuscular olanzapine in treating agitation associated with Alzheimer's di...
Comparison of Rapidly Acting Intramuscular Olanzapine, Lorazepam, and Placebo: A Double-blind, Randomized Study in Acutely Agitated Patients with Dementia This double-blind study investigated the efficacy and safety of rapid-acting intramuscular olanzapine in treating agitation associated with Alzheimer's di...
Like all benzodiazepines, lorazepam can cause physical dependence. Suddenly stopping therapy after a few months of daily therapy may be associated with a feeling of loss of self-worth, agitation, and insomnia. If lorazepam is taken continuously for longer than a few months, stopping therapy suddenl...
DementiaPsychomotor AgitationAcute DiseaseBenzodiazepinesPirenzepineAntipsychotic AgentsInjections, IntramuscularDouble-Blind MethodPsychiatric Status Rating ScalesThis double-blind study investigated the efficacy and safety of rapid-acting intramuscular olanzapine in treating agitation associated with Alzheimer's disease...
Injection 3 was given at least 1 h after injection 2. If a patient required treatment with another therapeutic agent for agitation after injection 3, that patient was discontinued from the study.Karena M. MeehanMRCPMRCPsychHuei WangPh.D
Comparison of Rapidly Acting Intramuscular Olanzapine, Lorazepam, and Placebo: A Double-blind, Randomized Study in Acutely Agitated Patients with Dementia This double-blind study investigated the efficacy and safety of rapid-acting intramuscular olanzapine in treating agitation associated with Alzheimer's di...