GRAPH theoryEVOLUTIONARY algorithmsEvolutionary dynamics in spatially structured populations has been studied for a long time. More recently, the focus has been to construct structures that amplify selection by
SelfLoops takes its name from the self-loop in graph theory, a self-loop is an edge that connects a vertex to itself. We are convinced that improvements can only be made if we have the ability to measure and analyze our activities and then act upon the past experiences and feedback. ...
Loop and domain nodes in their uni-modal graph representations were labeled using established ArchDB and SCOP nomenclature, respectively, arranged top-down in the order of time events, and colored according to age (nd) on a relative 0-to-1 scale or on a 'billions of years ago' (Gya) ...
Beyond perturbation theory much less is known in general, with the particular exception of those theories that admit a dual description in the strongly coupled sector, such as that provided by the AdS/CFT correspondence [2]. This correspondence is by far best understood for –1– the maximally...
Video S3. Motions associated with the principal component PC1 of PL3 loops in wild-type ClpB (left) and in the BB variant (right). To reveal allosteric paths connecting Walker B and pore-loop sites within a ClpB subunit, we resorted to a graph theory-based approach (39,40,41,42,43...
We present SiCLAT, which introduces a dCas9-dCas13d cassette into the mouse genome. This model enables the stable expression of both dCas9 and dCas13 proteins in diverse cell populations, facilitating concurrent labeling of DNA and RNA across various cel
Collisions between the DNA replication machinery and co-transcriptional R-loops can impede DNA synthesis and are a major source of genomic instability in cancer cells. How cancer cells deal with R-loops to proliferate is poorly understood. Here we show that the ATP-dependent chromatin remodelling ...
The AP cluster of the unbound conformer is labeled as au, and its canonical cluster is denoted as cu, in this case, c1. The AP cluster and canonical cluster of a bound conformation x are denoted as aB and cB on the graph. Comparing aB, cB with au,cu, we can define four types of...
(i.e., nodes in blue and orange). The AP cluster of the unbound conformer is labeled asau, and its canonical cluster is denoted ascu, in this case,on the graph. Comparinga,cwitha,cu, we can define four types of CDR conformational change upon binding: (1) identical AP cluster: the...
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