Previous studies have shown that removal of RNA from RNA/DNA hybrids impairs both homologous recombination (HR) and non-homologous end joining (NHEJ) DNA repair (Lu et al., 2018). Furthermore, localization of factors such as cockayne syndrome protein B to the sites of DNA damage is facilitat...
Considering these multiple pivotal roles of lncRNAs in nuclei, and the knowledge that RNA can be a fast-acting molecule for regulating cell functions in response to extracellular signals, lncRNAs may also regulate intrinsic RS via assisting in the removal of R-loops in cancer cells. In the ...
that induce DNA damage and activate the DNA damage response (DDR), such as cisplatin and carboplatin1, or drugs targeting DDR, such as Poly (ADP-Ribose) Polymerase inhibitors (PARPi)2 and Topoisomerase1 inhibitors (TOP1i)3,4, remain the mainstay of treatment after surgical tumor removal. ...
Another conclusion to be drawn is that possibly the subtraction scheme in IREG given by the removal of BDI's such as Il(nn)(λ2) may not correspond to the MS scheme or even the DS scheme. However, since this conclusion can only be ascertained by the computation of renormalization con- ...
After ethanol removal, the cells were treated with 40 µg/mL of Propidium Iodide and 0.1 µg/mL of RNaseA in 1 × PBS and incubated for 30 min at 37 °C. Stained cells were filtered through a cell strainer and incubated on ice before FACS analysis. Cell cycle analysis was ...
Coagulation and flocculation techniques, employed for the removal of suspended solids and colloidal substances from wastewater, may concurrently lead to the accumu- lation of heavy metals [38]. The coagulants used in these processes can contribute to the formation of sludge-containing metals. The ...