长时程抑制（LTD）是突触可塑性的重要形式，与学习记忆紧密相关。近十年的研究揭示了LTD的分子机制及其在进化上的高度保守性。LTD的诱导和维持涉及到多种关键分子，包括细胞膜受体、细胞信号转导通路、基因表达的调控因子。LTD的分子机制主要通过以下三个关键步骤实现：首先，爬行纤维的激活导致浦肯野细胞树...
1.Long-term depression (LTD) is one of the important forms in synaptic plasticity, and the reports show that it is related to learning and memory; however, the studies of which is difficult for a long time.长时程抑制(longtermdepression,LTD)是突触可塑性的重要形式之一,并且与学习记忆存在着密...
7.laboratory study on the treatment of Bushenyizhifang on Laboratory dementia rats;“补肾益智方”改善老年痴呆长时程增强现象的实验研究 8.Arginine Vasopressin Reversed Aβ_(25-35)-Induced Depression of Hippocampal Long-Term Potentiation in Rat in Vivo;精氨酸加压素逆转Aβ_(25-35)引起的在体大鼠海马...
突触可塑性包括长时程增强(long-term potentiation,LTP)、长时程抑制(long-term depression,LTD)、超可塑性被认为是学习和记忆的神经生物学基础,为从细胞或突触水平上理解学习记忆提供了很好的模型,也为筛选促智药、研究促智药作用机制提供了有利工具。
8.Arginine Vasopressin Reversed Aβ_(25-35)-Induced Depression of Hippocampal Long-Term Potentiation in Rat in Vivo;精氨酸加压素逆转Aβ_(25-35)引起的在体大鼠海马长时程增强的压抑 9.The Role of ERK-CREB Signaling Pathway in Long-term Potentiation and Working Memory in Rat Medial Prefrontal Cor...
8.Arginine Vasopressin Reversed Aβ_(25-35)-Induced Depression of Hippocampal Long-Term Potentiation in Rat in Vivo;精氨酸加压素逆转Aβ_(25-35)引起的在体大鼠海马长时程增强的压抑 9.The Role of ERK-CREB Signaling Pathway in Long-term Potentiation and Working Memory in Rat Medial Prefrontal Cor...