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Conclusions: AGAP2〢S1 facilitates cell proliferation, motility and EMT in CRC via targeting miR68/SRSF1 axis. AGAP2〢S1 or SRSF1 may become underlying therapeutic targets for CRC patients in the future.doi:10.1002/jgm.3250Hesheng LiDepartment of Gastrointestinal Surgery Binzhou Medical University ...
2.2. Role of lncRNA in tumor epithelial-to-mesenchymal transition (EMT) Epithelial-to-mesenchymal transition (EMT) is a highly conserved cellular process in which non-motile epithelial cells are transformed into migratory mesenchymal cells. EMT occurs during embryonic development, fibrosis, wound healin...
Backpacking could be defined as the art of comtortable,self-sufficiemt(自给自足)travel on foot. Everying you need is in the pack on your back, and you become emotionally as well as physically attached to it.I once left my pack hidden in some rocks while I made a long trip to a pea...
Long-term hypoxia adaptation leads to EMT-like morphological changes The intratumoral microenvironment develops hypoxia over an extended time frame, generating a continuum of oxygen concentrations, resulting in differential HIF1 activity (Fig. 1A) [15]. First, to monitor tumor cell adaptation to long...
The type II Cas protein in Streptococcus pyogenes has been shown to conduct RNA-guided DNA cutting in mammalian cells, opening a new stage in which CRISPR/Cas9 has become a widely used gene-editing tool. The CRISPR/Cas9 system includes a single guide RNA (sgRNA) and a Cas9 enzyme; sgRNA ...
leading to suppression of TCD8+cells and ultimately progression of cancer cells. Created inhttps://BioRender.com. CRC, colorectal cancer; M2 MQ, M2 macrophages; MDSCs, myeloid-derived suppressor cells; DCs, dendritic cells; lncRNA, long non-coding RNA; EMT, epithelial–mesenchymal transition; ...
Non–small‐cell lung cancer (NSCLC) has become the most lethal human cancer because of the high rate of metastasis. Hence, clarifying the molecular mechanism underlying NSCLC metastasis is very important to improve the prognosis of patients with NSCLC. Long non‐coding RNAs (LncRNAs) are a ...
Cancer stem cells (CSCs) have the capacity for self-renewal and they differentiate to produce cancer cells [62]. Cancer cells derived from CSC have genes that when expressed, induce epithelial-mesenchymal transition (EMT), which plays an important role in mediating metastasis [62, 63]. Emerging...
The epithelial to mesenchymal transition or EMT has become one of the most exciting fields in cancer research. Nevertheless, its relevance in tumor biology... MA Nieto,A Cano - 《Seminars in Cancer Biology》 被引量: 366发表: 2012年 P53-regulated long non-coding RNA TUG1 affects cell prolife...