The long-term safety of proton pump inhibitors (PPIs) is increasingly questioned. The aim of our study was to assess the risk of pancreatic cancer among lo
the medication is maintained for up to 12 months; (2) that there are no withdrawal symptoms associated with discontinuation of the treatment, even after 12 months; and (3) that normal endogenous melatonin levels are produced despite long-term administration (6 months) of PRM 2 mg....
the medication is maintained for up to 12 months; (2) that there are no withdrawal symptoms associated with discontinuation of the treatment, even after 12 months; and (3) that normal endogenous melatonin levels are produced despite long-term administration (6 months) of PRM 2 mg....
recurrence, a proton pump inhibitor exposure cumulative defined daily dose > 60 had reduced recurrence risk with an adjusted hazard ratio of 0.84 (95% CIs: 0.76–0.93). This study demonstrated that the long-term use of proton pump inhibitors in patients with colorectal cancer was associated with...
Some studies have also suggested a potential link between long-term PPI use and an increased risk of kidney disease as well as cardiovascular events, though the causal relationship remains a topic of investigation [10,11,12]. The association between proton pump inhibitors (PPIs) and an increased...