Proton pump inhibitors (PPIs) are the drugs of choice in the therapy of acid-related disorders. PPIs are as a class remarkably safe. Serious adverse events such as acute interstitial nephritis are extremely rare. Some reports in recent years have placed some concern on the long-term use of ...
ppitreatmenteffectsproducinglongsibo Effects of long-termPPI treatment on producing bowel symptoms and SIBO Debora Compare * , Loredana Pica * , Alba Rocco * , Francesco De Giorgi * , Rosario Cuomo * , Giovanni Sarnelli * , Marco Romano †,1 and Gerardo Nardone *,1 * Department of Clinica...
The objective of our study was to evaluate the cost-effectiveness of the long-term use of celecoxib compared with nsNSAIDs in a population of 60-year-old OA patients with average risks of upper gastrointestinal (UGI) complications who require chronic daily NSAID therapy. We assume that acetamino...
Streptococcus salivarius,Veillonella parvulaand the genusStreptococcuswere significantly increased in patients with long-term PPI therapy and performed well as biomarkers for PPI-associated dysbiosis (accuracy: 74%, 72% and 74%, respectively). The abundance ofStreptococcus salivariuswas linked to intestinal...
Conclusion Long-term PPI therapy, particularly at high doses, is associated with an increased risk of hip fracture. More than 47 000 hip fractures occur annually in the United Kingdom.1 Hip fracture is the main manifestation of senile osteoporosis, which results from secondary hyperparathyroidism ...
The use of warfarin in patients with non-valvular atrial fibrillation (NVAF) can be challenging. In this study, we evaluate the time in therapeutic range (TTR), health-related quality of life (HRQoL) and treatment satisfaction of patients on long-term warfarin for NVAF. The HRQoL and treatmen...
This study aimed to explore the prognostic and predictive value of autophagy-related lncRNAs in papillary thyroid carcinoma (PTC). The expression data of autophagy-related genes and lncRNAs of the PTC patients were obtained from TCGA database. Autophagy-
Drought stress is one of the potent abiotic stress limiting cassava (Manihot esculenta) yield globally, but studies addressing both physiological and proteomic responses that how cassava crops can adjust their growth and metabolism under drought conditio
To our knowledge, the only previous study examining down-titration from high long-term ICS doses is the study by Hawkins and colleagues7; in this study, with baseline mean ICS dose of 1400 μg beclomethasone equivalent, the aim was to assess whether ICS dose could be safely stepped down, ...
Pantoprazole is an irreversible proton pump inhibitor which, at the therapeutic dose of 40mg, effectively reduces gastric acid secretion. In controlled cli... A Fitton,L Wiseman - 《Drugs》 被引量: 475发表: 1996年 The use of proton pump inhibitors in children: a comprehensive review. PPI effi...