We applaud Notini and colleagues for highlighting the clinical and ethical complexities of a case in which a non-binary individual desires indefinite treatment with puberty blockers. 1 While we agree discontinuing treatment may cause psychological distress, we believe there are potential physical and ...
Although existing contraceptive strategies have been widely used in people's lives, there have not been satisfactory feedbacks due to low contraceptive efficacy and related side effects (e.g., decreased sexuality, menstrual cycle disorder, and even lifelong infertility). In recent years, biomaterials-...
During the rehabilitation program, no modification of the routine cardiac follow-up of the patient was observed, and the dosage of beta-blockers remained unchanged. Short-term efficacy The patient characteristics remained unchanged between baseline and the end of the cardiac rehabilitation program (n=...
The theory of delayed life history effects assumes that phenotype of adult individual results from environmental conditions experienced at birth and as juvenile. In seasonal environments, being born late in the reproductive season affects timing of puberty, body condition, longevity, and fitness. We hy...
healthcare Article Long-Term Melatonin Therapy for Adolescents and Young Adults with Chronic Sleep Onset Insomnia and Late Melatonin Onset: Evaluation of Sleep Quality, Chronotype, and Lifestyle Factors Compared to Age-Related Randomly Selected Population Cohorts Tom C. Zwart 1,2 ID , Marcel G. ...
None of our patients had signs of precocious puberty at diagnosis, and during further follow-up had normal stages of pubertal development. In our study, we have found that more than half of our survivors had low BMI. There was no clear correlation between the children’s BMI at birth, at...